Weight | 220.231 g/mol |
---|---|
Formula | C14H8N2O |
Hydrogen Acceptors | 2 |
Hydrogen Donors | 1 |
Aromatic Rings | 3 |
Rotatable Bonds | 0 |
1,9-Pyrazoloanthrone (129-56-6)
SP600125 · anthra(1,9-cd)pyrazol-6(2H)-one · NSC75890
Score:
#47 in Molecular and cellular biology
,
#1619 in Biochemistry
,
#3684 in Biology
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#4631 in Chemistry
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- Sigma-Aldrich - 1,9-Pyrazoloanthrone94.80 - 399.50 USD
- Fisher Scientific - Search for 1,9-Pyrazoloanthrone
- TCI - 1,9-Pyrazoloanthrone94.00 USD
- SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase (Proceedings of the National Academy of Sciences of the United States of America, 2001)
- Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125 (The EMBO Journal, 2004)
- An inhibitor of c-jun aminoterminal kinase (SP600125) represses c-Jun activation, DNA-binding and PMA-inducible 92-kDa type IV collagenase expression. (Biochimica et Biophysica Acta, 2002)
- The neuroprotective action of SP600125, a new inhibitor of JNK, on transient brain ischemia/reperfusion-induced neuronal death in rat hippocampal CA1 via nuclear and non-nuclear pathways (Brain Research, 2005)
- SP600125, a new JNK inhibitor, protects dopaminergic neurons in the MPTP model of Parkinson's disease (Neuroscience Research, 2004)
- c-Jun NH2-Terminal Kinase Inhibitor Anthra(1,9-cd)pyrazol-6(2H)-one Reduces Inducible Nitric-Oxide Synthase Expression by Destabilizing mRNA in Activated Macrophages (Molecular Pharmacology, 2003)
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Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - SP600125
- anthra(1,9-cd)pyrazol-6(2H)-one
- NSC75890
- NSC-75890
- pyrazolanthrone
- 2h-dibenzo(cd,g)indazol-6-one
-
SMILESC1=CC=C2C(=C1)C3=NNC4=CC=CC(=C43)C2=O
-
InChIKeyACPOUJIDANTYHO-UHFFFAOYSA-N
- Pubchem - 1,9-Pyrazoloanthrone
- Wikipedia - pyrazolanthrone
1,9-Pyrazoloanthrone is a chemical compound that is a derivative of anthrone. It is used in biochemical studies as an inhbitor of c-Jun N-terminal kinases (JNKs). Derivatives of 1,9-pyrazoloanthrone have a variety of biological activities.
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