| Weight | 164.157 g/mol |
|---|---|
| Formula | C6H12O5 |
| Hydrogen Acceptors | 5 |
| Hydrogen Donors | 4 |
| Aromatic Rings | 0 |
| Rotatable Bonds | 5 |
154-17-6 (154-17-6)
Deoxyglucose · 2 Deoxyglucose · 2-Deoxy-D-glucose
Score:
#934 in Neuroscience
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#1926 in Biochemistry
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#4096 in Biology
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#5162 in Chemistry
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- Sigma-Aldrich - 154-17-623.70 - 980.00 USD
- Fisher Scientific - Search for 154-17-6
- TCI - 154-17-643.00 - 513.00 USD
- THE [14C]DEOXYGLUCOSE METHOD FOR THE MEASUREMENT OF LOCAL CEREBRAL GLUCOSE UTILIZATION: THEORY, PROCEDURE, AND NORMAL VALUES IN THE CONSCIOUS AND ANESTHETIZED ALBINO RAT (Journal of Neurochemistry, 1977)
- Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose (Cell, 1986)
- Electrographic, clinical and pathological alterations following systemic administration of kainic acid, bicuculline or pentetrazole: Metabolic mapping using the deoxyglucose method with special reference to the pathology of epilepsy (Neuroscience, 1981)
- LOCALIZATION OF THE PRIMARY METABOLIC BLOCK PRODUCED BY 2-DEOXYGLUCOSE (Journal of Biological Chemistry, 1957)
- Localization of functional activity in the central nervous system by measurement of glucose utilization with radioactive deoxyglucose. (Journal of Cerebral Blood Flow and Metabolism, 1981)
- Fluorine-18 deoxyglucose and false-positive results: a major problem in the diagnostics of oncological patients (European Journal of Nuclear Medicine and Molecular Imaging, 1996)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Deoxyglucose
- 2 Deoxyglucose
- 2-Deoxy-D-glucose
- 2-Desoxy-D-glucose
- 2 Desoxy D glucose
- 2 Deoxy D glucose
- 2-Deoxyglucose
-
SMILESC(C=O)C(C(C(CO)O)O)O
-
InChIKeyVRYALKFFQXWPIH-UHFFFAOYSA-N
- Pubchem - 154-17-6
- Wikipedia - 2-deoxyglucose
2-Deoxy-D-glucose is a glucose molecule which has the 2-hydroxyl group replaced by hydrogen, so that it cannot undergo further glycolysis. As such; it acts to competitively inhibit the production of glucose-6-phosphate from glucose at the phosphoglucoisomerase level (step 2 of glycolysis). In most cells, glucose hexokinase phosphorylates 2-deoxyglucose, trapping the product 2-deoxyglucose-6-phosphate intracellularly (with exception of liver and kidney); thus, labelled forms of 2-deoxyglucose serve as a good marker for tissue glucose uptake and hexokinase activity.
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