| Weight | 221.687 g/mol |
|---|---|
| Formula | C12H12ClNO |
| Hydrogen Acceptors | 2 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 1 |
5,6-Dehydronorketamine (57683-62-2)
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SMILESC1CC(C(=O)C=C1)(C2=CC=CC=C2Cl)N
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InChIKeyBXBPJMHHWPXBJL-UHFFFAOYSA-N
- Pubchem - 5,6-Dehydronorketamine
- Wikipedia - Dehydronorketamine
Dehydronorketamine (DHNK), or 5,6-dehydronorketamine, is a minor metabolite of ketamine which is formed by dehydrogenation of its metabolite norketamine. Though originally considered to be inactive, DHNK has been found to act as a potent and selective negative allosteric modulator of the 7-nicotinic acetylcholine receptor (IC50 = 55 nM). For this reason, similarly to hydroxynorketamine (HNK), it has been hypothesized that DHNK may have the capacity to produce rapid antidepressant effects.
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