| Weight | 392.411 g/mol |
|---|---|
| Formula | C22H20N2O5 |
| Hydrogen Acceptors | 7 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 2 |
7-Ethyl-10-hydroxycamptothecin (86639-52-3)
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- Common Human UGT1A Polymorphisms and the Altered Metabolism of Irinotecan Active Metabolite 7-Ethyl-10-hydroxycamptothecin (SN-38) (Molecular Pharmacology, 2002)
- ROLE OF ORGANIC ANION TRANSPORTER OATP1B1 (OATP-C) IN HEPATIC UPTAKE OF IRINOTECAN AND ITS ACTIVE METABOLITE, 7-ETHYL-10-HYDROXYCAMPTOTHECIN: IN VITRO EVIDENCE AND EFFECT OF SINGLE NUCLEOTIDE POLYMORPHISMS (Drug Metabolism and Disposition, 2004)
- Synthesis and Antitumor Activity of 20(S)-Camptothecin Derivatives: Carbamate-Linked, Water-Soluble Derivatives of 7-Ethyl-10-hydroxycamptothecin. (Chemical & Pharmaceutical Bulletin, 1991)
- The HER Tyrosine Kinase Inhibitor CI1033 Enhances Cytotoxicity of 7-Ethyl-10-hydroxycamptothecin and Topotecan by Inhibiting Breast Cancer Resistance Protein-mediated Drug Efflux (Cancer Research, 2001)
- Conversion of irinotecan (CPT-11) to its active metabolite, 7-ethyl-10-hydroxycamptothecin (SN-38), by human liver carboxylesterase (Biochemical Pharmacology, 1996)
- Novel Functional Polymorphisms in the UGT1A7 and UGT1A9 Glucuronidating Enzymes in Caucasian and African-American Subjects and Their Impact on the Metabolism of 7-Ethyl-10- hydroxycamptothecin and Flavopiridol Anticancer Drugs (Journal of Pharmacology and Experimental Therapeutics, 2003)
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SMILESCCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)O
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InChIKeyFJHBVJOVLFPMQE-UHFFFAOYSA-N
- Pubchem - 7-Ethyl-10-hydroxycamptothecin
- Wikipedia - 7-ethyl-10-hydroxycamptothecin
SN-38 is an antineoplastic drug. It is the active metabolite of irinotecan (an analog of camptothecin - a topoisomerase I inhibitor) but has 1000 times more activity than irinotecan itself. In vitro cytotoxicity assays show that the potency of SN-38 relative to irinotecan varies from 2- to 2000-fold.
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7-Ethyl-10-hydroxycamptothecin
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