| Weight | 226.659 g/mol |
|---|---|
| Formula | C11H11ClO3 |
| Hydrogen Acceptors | 2 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 5 |
alclofenac (22131-79-9)
Mervan · 4-allyloxy-3-chlorophenylacetic acid · Prinalgin
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- Hydrophilic and Hydrophobic Polymeric Derivatives of Anti-Inflammatory Agents Such as Alclofenac, Ketoprofen, and Ibuprofen (Journal of Bioactive and Compatible Polymers, 1991)
- Long-term study of indomethacin and alclofenac in treatment of rheumatoid arthritis. (BMJ, 1975)
- The destruction of cytochrome P-450 by alclofenac: Possible involvement of an epoxide metabolite (Biochemical Pharmacology, 1982)
- Alclofenac: a review of its pharmacological properties and therapeutic efficacy in rheumatoid arthritis and allied rheumatic disorders. (Drugs, 1977)
- Renal papillary necrosis after aspirin and alclofenac. (BMJ, 1977)
- Kinetic studies on the absorption and excretion of 4-allyloxy-3-chlorphenylacetic-acid (alclofenac) in man (European Journal of Clinical Pharmacology, 1971)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Mervan
- 4-allyloxy-3-chlorophenylacetic acid
- Prinalgin
-
SMILESC=CCOC1=C(C=C(C=C1)CC(=O)O)Cl
-
InChIKeyARHWPKZXBHOEEE-UHFFFAOYSA-N
- Pubchem - alclofenac
- Wikipedia - alclofenac
Alclofenac is a nonsteroidal anti-inflammatory drug (NSAID).
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Synthesis
Reactant
+
dimethyl sulfide
(Corey-Kim oxidation of secondary alcohols)
Reactant
+
1-Hydroxy-1,2-benziodoxol-3(1H)-one 1-oxide
(Nicolaou IBX dehydrogenation)
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alclofenac
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