Weight | 294.358 g/mol |
---|---|
Formula | C17H18N4O |
Hydrogen Acceptors | 3 |
Hydrogen Donors | 1 |
Aromatic Rings | 3 |
Rotatable Bonds | 2 |
alosetron (122852-42-0)
Lotronex · alosetron hydrochloride · alosetron monohydrochloride
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- Efficacy and safety of alosetron in women with irritable bowel syndrome: a randomised, placebo-controlled trial (The Lancet, 2000)
- Improvement in pain and bowel function in female irritable bowel patients with alosetron, a 5-HT3 receptor antagonist (Alimentary Pharmacology & Therapeutics, 1999)
- A Randomized Controlled Clinical Trial of the Serotonin Type 3 Receptor Antagonist Alosetron in Women With Diarrhea-Predominant Irritable Bowel Syndrome (JAMA Internal Medicine, 2001)
- Effect of alosetron on responses to colonic distension in patients with irritable bowel syndrome (Alimentary Pharmacology & Therapeutics, 1998)
- Efficacy of alosetron in irritable bowel syndrome: a meta-analysis of randomized controlled trials (Neurogastroenterology and Motility, 2003)
- Alosetron controls bowel urgency and provides global symptom improvement in women with diarrhea-predominant irritable bowel syndrome (The American Journal of Gastroenterology, 2001)
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Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Lotronex
- alosetron hydrochloride
- alosetron monohydrochloride
- 2,3,4,5-tetrahydro-5-methyl-2-((5-methylimidazol-4-yl)methyl)-1H-pyrido(4,3-b)indol-1-one monohydrochloride
- GR 68755
- GR68755
- GlaxoSmithKline brand of alosetron hydrochloride
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SMILESCC1=C(N=CN1)CN2CCC3=C(C2=O)C4=CC=CC=C4N3C
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- Pubchem - alosetron
- Wikipedia - alosetron
Alosetron (original brand name: Lotronex LOH-tron-eks; originator: GSK) is a 5-HT3 antagonist used for the management of severe diarrhea-predominant irritable bowel syndrome (IBS) in women only. It is currently marketed by Prometheus Laboratories Inc. (San Diego).
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