Weight | 249.354 g/mol |
---|---|
Formula | C15H23NO2 |
Hydrogen Acceptors | 3 |
Hydrogen Donors | 2 |
Aromatic Rings | 1 |
Rotatable Bonds | 8 |
alprenolol (13655-52-2)
Aptin · Alpheprol · Alprenolol Hydrochloride
Score:
#1078 in Biochemistry
,
#2788 in Biology
,
#3494 in Chemistry
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- REDUCTION OF SUDDEN DEATHS AFTER MYOCARDIAL INFARCTION BY TREATMENT WITH ALPRENOLOL: Preliminary Results (The Lancet, 1974)
- Identification of beta-adrenergic receptors in human lymphocytes by (-) (3H) alprenolol binding. (Journal of Clinical Investigation, 1976)
- Rapid changes in rat pineal beta-adrenergic receptor: alterations in l-(3H)alprenolol binding and adenylate cyclase (Proceedings of the National Academy of Sciences of the United States of America, 1975)
- Stereospecific [3H]()-alprenolol binding sites, -adrenergic receptors and adenylate cyclase (Biochemical and Biophysical Research Communications, 1974)
- EFFECT OF ALPRENOLOL ON MORTALITY AMONG PATIENTS WITH DEFINITE OR SUSPECTED ACUTE MYOCARDIAL INFARCTION: Preliminary Results (The Lancet, 1979)
- -Blockers alprenolol and carvedilol stimulate -arrestin-mediated EGFR transactivation (Proceedings of the National Academy of Sciences of the United States of America, 2008)
-
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Aptin
- Alpheprol
- Alprenolol Hydrochloride
- Aptina
- H 56 28
- Aptine
- AptinDuriles
- Alfeprol
- 1-(o-Allylphenoxy)-3-(isopropylamino)-2-propanol
- H-56-28
- Aptin Duriles
- Aptin-Duriles
- H5628
-
SMILESCC(C)NCC(COC1=CC=CC=C1CC=C)O
-
InChIKeyPAZJSJFMUHDSTF-UHFFFAOYSA-N
- Pubchem - alprenolol
- Wikipedia - alprenolol
Alprenolol, or alfeprol, alpheprol, and alprenololum (Gubernal, Regletin, Yobir, Apllobal, Aptine, Aptol Duriles), is a non-selective beta blocker as well as a 5-HT1A and 5-HT1B receptor antagonist, used in the treatment of angina pectoris. It is no longer marketed by AstraZeneca, but may still be available from other pharmaceutical companies or generically.
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Synthesis
ISOPROPYLAMINE
+
Reactant
(Alkylation of primary amines)
Reactant
+
CID 5475562
(Chan-Lam coupling reaction)
2-ALLYLPHENOL
+
Reactant
(Williamson ether)
Reactant
+
1-Hydroxy-1,2-benziodoxol-3(1H)-one 1-oxide
(Nicolaou IBX dehydrogenation)
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