Score: #1181 in Neuroscience , #5093 in Biology

  AM cannabinoid · Analgesic · Aromatic compound · Cannabinoid · Cannabinoid · Cannabi · Categories by psychoactive drug · Chloroarene · Cyclic compound · Drugs acting on the nervous system · Five-membered ring · Iodoarene · Opioid antagonist · Opioid receptor ligand · Opioid · Piperidine · Psychoactive drug · Psychoactive drug · Psychoactive drugs by mechanism of action · Pyrazolecarboxamide · Pyrazole · Six-membered ring

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Suppliers

• Sigma-Aldrich - AM251
  204.00 - 699.00 USD
• Fisher Scientific - Search for AM251
• TCI - Search for AM251

Most-cited Publications

• 123I-labeled AM251: a radioiodinated ligand which binds in vivo to mouse brain cannabinoid CB1 receptors (European Journal of Pharmacology, 1996)
• Antidepressant-like and anorectic effects of the cannabinoid CB1 receptor inverse agonist AM251 in mice. (Behavioural Pharmacology, 2003)
• The cannabinoid CB1 antagonists SR 141716A and AM 251 suppress food intake and food-reinforced behavior in a variety of tasks in rats. (Behavioural Pharmacology, 2003)
• Binding of the non-classical cannabinoid CP 55,940, and the diarylpyrazole AM251 to rodent brain cannabinoid receptors (Life Sciences, 1997)
• Cannabinoid CB1 Receptor Antagonist AM251 Inhibits Cocaine-Primed Relapse in Rats: Role of Glutamate in the Nucleus Accumbens (The Journal of Neuroscience, 2006)
• Cannabinoid (CB)1 receptor antagonist, AM 251, causes a sustained reduction of daily food intake in the rat (Physiology & Behavior, 2004)

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Alternate Names

• AM 251
• N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxamide
• N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide
• AM-251
• SMILES
  CC1=C(N(N=C1C(=O)NN2CCCCC2)C3=C(C=C(C=C3)Cl)Cl)C4=CC=C(C=C4)I
• InChIKey
  BUZAJRPLUGXRAB-UHFFFAOYSA-N

External Links

• Pubchem - AM251
• Wikipedia - am-251
  AM-251 is an inverse agonist at the CB1 cannabinoid receptor. AM-251 is structurally very close to SR141716A (rimonabant); both are biarylpyrazole cannabinoid receptor antagonists. In AM-251 the p-chloro group attached to the phenyl substituent at C-5 of the pyrazole ring is replaced with a p-iodo group.

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