| Weight | 317.517 g/mol |
|---|---|
| Formula | C21H35NO |
| Hydrogen Acceptors | 2 |
| Hydrogen Donors | 0 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 6 |
Amorolfine (78613-35-1, 67467-83-8)
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- A randomized trial of amorolfine 5% solution nail lacquer combined with oral terbinafine compared with terbinafine alone in the treatment of dermatophytic toenail onychomycoses affecting the matrix region (British Journal of Dermatology, 2000)
- Comparative efficacy and safety of amorolfine nail lacquer 5% in onychomycosis, once-weekly versus twice-weekly. (Clinical and Experimental Dermatology, 1992)
- Comparative efficacy and safety of amorolfine nail lacquer 2% versus 5% once weekly (Clinical and Experimental Dermatology, 1992)
- A multicentre, randomized, controlled study of the efficacy, safety and cost-effectiveness of a combination therapy with amorolfine nail lacquer and oral terbinafine compared with oral terbinafine alone for the treatment of onychomycosis with matrix involvement (British Journal of Dermatology, 2007)
- Therapeutic Efficacy of Topically Applied KP-103 against Experimental Tinea Unguium in Guinea Pigs in Comparison with Amorolfine and Terbinafine (Antimicrobial Agents and Chemotherapy, 2002)
- Amorolfine. A review of its pharmacological properties and therapeutic potential in the treatment of onychomycosis and other superficial fungal infections. (Drugs, 1995)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCCC(C)(C)C1=CC=C(C=C1)CC(C)CN2CC(OC(C2)C)C
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- Pubchem - Amorolfine
- Wikipedia - amorolfine
Amorolfine (or amorolfin), is a morpholine antifungal drug that inhibits 14-sterol reductase and cholestenol -isomerase, which depletes ergosterol and causes ignosterol to accumulate in the fungal cytoplasmic cell membranes. Marketed as Curanail, Loceryl, Locetar, and Odenil, amorolfine is commonly available in the form of a nail lacquer, containing 5% amorolfine hydrochloride as the active ingredient. It is used to treat onychomycosis (fungal infection of the toe- and fingernails).
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