| Weight | 455.971 g/mol |
|---|---|
| Formula | C22H22ClN5O2S |
| Hydrogen Acceptors | 7 |
| Hydrogen Donors | 0 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 4 |
Apafant (105219-56-5)
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- Infarct reduction by the platelet activating factor antagonist apafant in rats. (Stroke, 1992)
- Pharmacological characterization of a receptor for platelet-activating factor on guinea pig peritoneal macrophages using [3H]apafant, a selective and competitive platelet-activating factor antagonist: evidence that the noncompetitive behavior of apafant in functional studies relates to slow kinetics of dissociation. (Molecular Pharmacology, 1993)
- Altered drug disposition of the platelet activating factor antagonist apafant in mdr1a knockout mice (European Journal of Pharmaceutical Sciences, 2002)
- PHARMACODYNAMICS, PHARMACOKINETICS AND SAFETY PROFILE OF THE NEW PLATELET-ACTIVATING FACTOR ANTAGONIST APAFANT IN MAN (Drug Research, 1991)
- The role of platelet activating factor and the efficacy of apafant ophthalmic solution in experimental allergic conjunctivitis. (Journal of Ocular Pharmacology and Therapeutics, 2003)
- Apafant, a Potent Platelet-Activating Factor Antagonist, Blocks Eosinophil Activation and Is Effective in the Chronic Phase of Experimental Allergic Conjunctivitis in Guinea Pigs (Journal of Pharmacological Sciences, 2004)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC1=NN=C2N1C3=C(C=C(S3)CCC(=O)N4CCOCC4)C(=NC2)C5=CC=CC=C5Cl
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InChIKeyJGPJQFOROWSRRS-UHFFFAOYSA-N
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