| Weight | 266.341 g/mol |
|---|---|
| Formula | C14H22N2O3 |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 3 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 8 |
atenolol (29122-68-7, 60966-51-0)
Tenormin · ICI66082 · ICI-66082
Score:
#328 in Biochemistry
,
#1223 in Biology
,
#1404 in Chemistry
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- Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol (The Lancet, 2002)
- Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial. (The Lancet, 2005)
- Effect of Atenolol on Mortality and Cardiovascular Morbidity after Noncardiac Surgery (The New England Journal of Medicine, 1996)
- Efficacy of atenolol and captopril in reducing risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 39 (BMJ, 1998)
- Cardiovascular morbidity and mortality in patients with diabetes in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol (The Lancet, 2002)
- Angiotensin II receptor blockade reduces new-onset atrial fibrillation and subsequent stroke compared to atenolol : The Losartan Intervention For End point reduction in hypertension (LIFE) study (Journal of the American College of Cardiology, 2005)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Tenormin
- ICI66082
- ICI-66082
- ICI 66082
- Tenormine
-
SMILESCC(C)NCC(COC1=CC=C(C=C1)CC(=O)N)O
-
InChIKeyMETKIMKYRPQLGS-UHFFFAOYSA-N
- Pubchem - atenolol
- Wikipedia - atenolol
Atenolol is a selective 1 receptor antagonist, a drug belonging to the group of beta blockers (sometimes written -blockers), a class of drugs used primarily in cardiovascular diseases. Introduced in 1976, atenolol was developed as a replacement for propranolol in the treatment of hypertension. It works by slowing down the heart and reducing its workload.
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Synthesis
Reactant
+
ISOPROPYLAMINE
(Reductive amination)
4-Hydroxyphenylacetamide
+
Reactant
(Williamson ether)
2-(Propan-2-ylamino)acetaldehyde
+
Reactant
(Grignard alcohol)
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