| Weight | 269.388 g/mol |
|---|---|
| Formula | C18H23NO |
| Hydrogen Acceptors | 2 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 8 |
Bifemelane (62232-46-6, 90293-01-9)
MCI-2016 · 2-(4-methylaminobutoxy)diphenylmethane · Celeport
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- Potential Antidepressive Properties of Amantadine, Memantine and Bifemelane (Pharmacology & Toxicology, 1993)
- Effects of bifemelane hydrochloride (MCI-2016) on acetylcholine level reduced by scopolamine, hypoxia and ischemia in the rats and Mongolian gerbils. (Japanese Journal of Pharmacology, 1985)
- EFFECT OF 4-(o-BENZYLPHENOXY)-N-METHYLBUTYLAMINE HYDROCHLORIDE (MCI-2016) ON THE SCOPOLAMINE-INDUCED DEFICIT OF SPONTANEOUS ALTERNATION BEHAVIOR IN RATS (Japanese Journal of Pharmacology, 1983)
- The use of Xenopus oocytes to evaluate drugs affecting brain Ca2+ channels : effects of bifemelane and several nootropic agents (European Journal of Pharmacology, 1990)
- Effects of Bifemelane on Muscarinic Receptors and Choline Acetyltransferase in the Brains of Aged Rats Following Chronic Cerebral Hypoperfusion Induced by Permanent Occlusion of Bilateral Carotid Arteries (Japanese Journal of Pharmacology, 1996)
- Effects of 4-(o-benzylphenoxy)-N-methylbutylamine hydrochloride (MCI-2016) on survival time and brain monoamine levels in bilaterally carotid-artery-ligated gerbils. (Japanese Journal of Pharmacology, 1984)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - MCI-2016
- 2-(4-methylaminobutoxy)diphenylmethane
- Celeport
- bifemelane hydrochloride
- 4-(2-benzylphenoxy)-N-methylbutylamine
- MCI 2016
-
SMILESCNCCCCOC1=CC=CC=C1CC2=CC=CC=C2
-
InChIKeyQSQQPMHPCBLLGX-UHFFFAOYSA-N
- Pubchem - Bifemelane
- Wikipedia - bifemelane
Bifemelane (INN) (Alnert, Celeport), or bifemelane hydrochloride (JAN), also known as 4-(O-benzylphenoxy)-N-methylbutylamine, is an antidepressant and cerebral activator that is widely used in the treatment of cerebral infarction patients with depressive symptoms in Japan, and in the treatment of senile dementia as well. It also appears to be useful in the treatment of glaucoma. Bifemelane acts as a monoamine oxidase inhibitor (MAOI) of both isoenzymes, with competitive (reversible) inhibition of MAO-A (Ki = 4.20 M) (making it a reversible inhibitor of monoamine oxidase A (RIMA)) and non-competitive (irreversible) inhibition of MAO-B (Ki = 46.0 M), and also acts (weakly) as a norepinephrine reuptake inhibitor.
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