| Weight | 463.622 g/mol |
|---|---|
| Formula | C28H37N3O3 |
| Hydrogen Acceptors | 5 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 10 |
Bilastine (202189-78-4)
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- Comparison of the efficacy and safety of bilastine 20 mg vs desloratadine 5 mg in seasonal allergic rhinitis patients (Allergy, 2009)
- Efficacy and safety of bilastine 20 mg compared with cetirizine 10 mg and placebo for the symptomatic treatment of seasonal allergic rhinitis: a randomized, double-blind, parallel-group study (Clinical & Experimental Allergy, 2009)
- Comparison of the efficacy and safety of bilastine 20 mg vs levocetirizine 5 mg for the treatment of chronic idiopathic urticaria: a multi-centre, double-blind, randomized, placebo-controlled study. (Allergy, 2010)
- Preclinical pharmacology of bilastine, a new selective histamine H1 receptor antagonist: receptor selectivity and in vitro antihistaminic activity. (Drugs in R & D, 2005)
- Up-dosing with bilastine results in improved effectiveness in cold contact urticaria (Allergy, 2013)
- In Vivo Pharmacological Characterisation of Bilastine, a Potent and Selective Histamine H1 Receptor Antagonist (Drugs in R & D, 2006)
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Predict GHS Hazards for Any Chemical in silico.
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SMILESCCOCCN1C2=CC=CC=C2N=C1C3CCN(CC3)CCC4=CC=C(C=C4)C(C)(C)C(=O)O
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InChIKeyACCMWZWAEFYUGZ-UHFFFAOYSA-N
- Pubchem - Bilastine
- Wikipedia - bilastine
Bilastine (trade name Bilaxten) is a second generation antihistamine drug for the treatment of allergic rhinoconjunctivitis and urticaria (hives). It exerts its effect as a selective histamine H1 receptor antagonist, and has an effectiveness similar to cetirizine, fexofenadine and desloratadine. It was developed in Spain by FAES Farma.
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Synthesis
1-(2-ethoxy-ethyl)-1H-benzoimidazole
+
Reactant
(Friedel-Crafts alkylation)
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