| Weight | 451.379 g/mol |
|---|---|
| Formula | C20H20Cl2N4O2S |
| Hydrogen Acceptors | 6 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 7 |
Capravirine (178979-85-6)
AG-1549
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- In vitro selection of mutations in human immunodeficiency virus type 1 reverse transcriptase that confer resistance to capravirine, a novel nonnucleoside reverse transcriptase inhibitor (Antiviral Research, 2006)
- Synthesis of 2-(aminocarbonylmethylthio)-1H-imidazoles as novel capravirine analogues (Bioorganic & Medicinal Chemistry, 2005)
- A simple sequential incubation method for deconvoluting the complicated sequential metabolism of capravirine in humans. (Drug Metabolism and Disposition, 2005)
- Metabolism and excretion of capravirine, a new non-nucleoside reverse transcriptase inhibitor, alone and in combination with ritonavir in healthy volunteers. (Drug Metabolism and Disposition, 2004)
- Capravirine, a Nonnucleoside Reverse-Transcriptase Inhibitor in Patients Infected with HIV-1: A Phase 1 Study (The Journal of Infectious Diseases, 2004)
- Identification of enzymes responsible for primary and sequential oxygenation reactions of capravirine in human liver microsomes (Drug Metabolism and Disposition, 2006)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - AG-1549
-
SMILESCC(C)C1=C(N(C(=N1)COC(=O)N)CC2=CC=NC=C2)SC3=CC(=CC(=C3)Cl)Cl
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InChIKeyYQXCVAGCMNFUMQ-UHFFFAOYSA-N
- Pubchem - Capravirine
- Wikipedia - capravirine
Capravirine was a non-nucleoside reverse transcriptase inhibitor which reached phase II trials before development was discontinued by Pfizer. Both phase IIb trials which were conducted failed to demonstrate that therapy with capravirine provided any significant advantage over existing triple-drug HIV therapies, and pharmacology studies showed that capravirine may interact with other HIV drugs.
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