| Weight | 293.087 g/mol |
|---|---|
| Formula | C7H15Cl2N2O4P |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 0 |
| Rotatable Bonds | 9 |
Carboxyphosphamide (22788-18-7)
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- Phenotypically Deficient Urinary Elimination of Carboxyphosphamide after Cyclophosphamide Administration to Cancer Patients (Cancer Research, 1988)
- Kinetic characterization of the catalysis of activated cyclophosphamide (4-hydroxycyclophosphamide/aldophosphamide) oxidation to carboxyphosphamide by mouse hepatic aldehyde dehydrogenases (Biochemical Pharmacology, 1988)
- Inhibition by cyanamide of 4-hydroxycyclophosphamide/aldophosphamide oxidation to carboxyphosphamide (Biochemical Pharmacology, 1981)
- Carboxyphosphamide: NMR studies of its stability and cell membrane permeability. (Drug Metabolism and Disposition, 1992)
- Oxidation of aldophosphamide to carboxyphosphamide by murine nad-linked aldehyde dehydrogenase. Abstr. (1976)
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Predict GHS Hazards for Any Chemical in silico.
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SMILESC(COP(=O)(N)N(CCCl)CCCl)C(=O)O
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- Pubchem - Carboxyphosphamide
- Wikipedia - carboxyphosphamide
Carboxycyclophosphamide is an inactive metabolite of the cytotoxic antineoplastic drug cyclophosphamide. In the metabolic pathway of cyclophosphamide inactivation it first metabolizes to 4-hydroxycyclophosphamide, then partially tautomerizes into aldophosphamide. Aldophosphamide then, in turn, is oxidized into carboxycyclophosphamide by the enzyme ALDH (aldehyde dehydrogenase).
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