| Weight | 289.81 g/mol |
|---|---|
| Formula | C16H20ClN3 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 0 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 6 |
Chloropyramine (59-32-5)
chlorpyramine · N-(p-chlorobenzyl)-N-(2-pyridyl)-N',N''-dimethylethylenediamine · chloropyramine hydrochloride
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- POSSIBLE TERATOGENICITY OF IMIPRAMINE/CHLOROPYRAMINE (The Lancet, 1973)
- Small molecule chloropyramine hydrochloride (C4) targets the binding site of focal adhesion kinase and vascular endothelial growth factor receptor 3 and suppresses breast cancer growth in vivo. (Journal of Medicinal Chemistry, 2009)
- Chloropyramine tetrachlorocuprate(II) (Acta Crystallographica Section C-crystal Structure Communications, 1997)
- SASH1 mediates sensitivity of breast cancer cells to chloropyramine and is associated with prognosis in breast cancer (Oncotarget, 2016)
- Development and validation of GC-MS method for analysis of chloropyramine hydrochloride in ointments (2015)
- Abstract 4257: Pharmacokinetics (PK) and tissue penetration of the novel VEGFR-3/FAK inhibitor, Chloropyramine (Cancer Research, 2011)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - chlorpyramine
- N-(p-chlorobenzyl)-N-(2-pyridyl)-N',N''-dimethylethylenediamine
- chloropyramine hydrochloride
- halopyramine
- Avapena
- Suprastin
- chloropyramine monohydrochloride
-
SMILESCN(C)CCN(CC1=CC=C(C=C1)Cl)C2=CC=CC=N2
-
InChIKeyICKFFNBDFNZJSX-UHFFFAOYSA-N
- Pubchem - Chloropyramine
- Wikipedia - chloropyramine
Chloropyramine is a classical ("old" or first generation) antihistamine drug approved in some Eastern European countries (like Russia) for the treatment of allergic conjunctivitis, allergic rhinitis, bronchial asthma, and other atopic (allergic) conditions. Related indications for clinical use include angioedema (Quincke's edema), allergic reactions to insect bites, food and drug allergies, and anaphylactic shock. Chloropyramine is known as a competitive reversible H1 receptor antagonist (also known as an H1 inverse agonist), meaning that it exerts its pharmacological action by competing with histamine for the H1 subtype histamine receptor.
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