| Weight | 333.453 g/mol |
|---|---|
| Formula | C18H23NO3S |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 5 |
ciglitazone (74772-77-3)
5-(4-(1-methylcyclohexylmethoxy)benzyl)thiazolidine-2,4-dione · ADD-3878 · ciglitizone
Score:
#75 in Molecular and cellular biology
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#1014 in Neuroscience
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#2172 in Biochemistry
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#4435 in Biology
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- Reduction of Insulin Resistance in Obese and/or Diabetic Animals by 5-[4-(1-Methylcyclohexylmethoxy)benzyl]-thiazolidine-2,4-dione (ADD-3878, U-63,287, Ciglitazone), a New Antidiabetic Agent (Diabetes, 1983)
- Studies on Antidiabetic Agents. II. Synthesis of 5-[4-(1-Methylcyclohexylmethoxy)-benzyl] thiazolidine-2, 4-dione (ADD-3878) and Its Derivatives (Chemical & Pharmaceutical Bulletin, 1982)
- Peroxisome Proliferator Activator Receptor- Ligands, 15-Deoxy-12,14-Prostaglandin J2 and Ciglitazone, Reduce Systemic Inflammation in Polymicrobial Sepsis by Modulation of Signal Transduction Pathways (Journal of Immunology, 2003)
- MAP Kinase Cascades Are Activated in Astrocytes and Preadipocytes by 15-Deoxy-1214-prostaglandin J2 and the Thiazolidinedione Ciglitazone through Peroxisome Proliferator Activator Receptor -independent Mechanisms Involving Reactive Oxygenated Species (Journal of Biological Chemistry, 2002)
- Ciglitazone, a New Hypoglycemic Agent: I. Studies in ob/ob and db/db Mice, Diabetic Chinese Hamsters, and Normal and Streptozotocin-Diabetic Rats (Diabetes, 1983)
- The Peroxisome Proliferator-Activated Receptor (PPAR) Ligands 15-Deoxy-12,14-Prostaglandin J2 and Ciglitazone Induce Human B Lymphocyte and B Cell Lymphoma Apoptosis by PPAR-Independent Mechanisms (Journal of Immunology, 2006)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - 5-(4-(1-methylcyclohexylmethoxy)benzyl)thiazolidine-2,4-dione
- ADD-3878
- ciglitizone
- ADD 3878
-
SMILESCC1(CCCCC1)COC2=CC=C(C=C2)CC3C(=O)NC(=O)S3
-
InChIKeyYZFWTZACSRHJQD-UHFFFAOYSA-N
- Pubchem - ciglitazone
- Wikipedia - ciglitazone
Ciglitazone (INN) is a thiazolidinedione. Developed by Takeda Pharmaceuticals in the early 1980s, it is considered the prototypical compound for the thiazolidinedione class. Ciglitazone was never used as a medication, but it sparked interest in the effects of thiazolidinediones.
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ciglitazone
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