| Weight | 343.423 g/mol |
|---|---|
| Formula | C20H25NO4 |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 5 |
Cilomilast (153259-65-5)
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- Cilomilast, a selective phosphodiesterase-4 inhibitor for treatment of patients with chronic obstructive pulmonary disease: a randomised, dose-ranging study (The Lancet, 2001)
- Antiinflammatory Effects of the Phosphodiesterase-4 Inhibitor Cilomilast (Ariflo) in Chronic Obstructive Pulmonary Disease (American Journal of Respiratory and Critical Care Medicine, 2003)
- Cilomilast: a second generation phosphodiesterase 4 inhibitor for asthma and chronic obstructive pulmonary disease (Expert Opinion on Investigational Drugs, 2001)
- Effect of cilomilast (Ariflo) on TNF-, IL-8, and GM-CSF release by airway cells of patients with COPD (Thorax, 2003)
- Cilomilast for COPD: Results of a 6-Month, Placebo-Controlled Study of a Potent, Selective Inhibitor of Phosphodiesterase 4 (Chest, 2006)
- An update and appraisal of the cilomilast Phase III clinical development programme for chronic obstructive pulmonary disease (British Journal of Clinical Pharmacology, 2006)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCOC1=C(C=C(C=C1)C2(CCC(CC2)C(=O)O)C#N)OC3CCCC3
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- Pubchem - Cilomilast
- Wikipedia - Cilomilast
Cilomilast (INN, codenamed SB-207,499, proposed trade name Ariflo) is a drug which was developed for the treatment of respiratory disorders such as asthma and chronic obstructive pulmonary disease (COPD). It is orally active and acts as a selective phosphodiesterase-4 inhibitor. Phosphodiesterase (PDE) inhibitors, such as theophylline, have been used to treat COPD for centuries; however, the clinical benefits of these agents have never been shown to outweigh the risks of their numerous adverse effects.
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