| Weight | 244.891 g/mol |
|---|---|
| Formula | CH4Cl2O6P2 |
| Hydrogen Acceptors | 2 |
| Hydrogen Donors | 4 |
| Aromatic Rings | 0 |
| Rotatable Bonds | 2 |
Clodronic Acid (10596-23-3)
Clodronate · Dichloromethylene Diphosphonate · Clodronate Disodium
Score:
#1099 in Biochemistry
,
#2823 in Biology
,
#3537 in Chemistry
"What do you need help with?"
LabBot
- Sigma-Aldrich - Search for Clodronic Acid
- Fisher Scientific - Search for Clodronic Acid
- TCI - Search for Clodronic Acid
- Reduction in new metastases in breast cancer with adjuvant clodronate treatment (The New England Journal of Medicine, 1998)
- Double-blind controlled trial of oral clodronate in patients with bone metastases from breast cancer. (Journal of Clinical Oncology, 1993)
- Effect of ethane-1-hydroxy-1,1-diphosphonate (EHDP) and dichloromethylene diphosphonate (Cl 2 MDP) on the calcification and resorption of cartilage and bone in the tibial epiphysis and metaphysis of rats. (Calcified Tissue International, 1973)
- Clodronate-liposome-mediated depletion of tumour-associated macrophages: a new and highly effective antiangiogenic therapy approach (British Journal of Cancer, 2006)
- Clodronate and liposome-encapsulated clodronate are metabolized to a toxic ATP analog, adenosine 5'-(,-dichloromethylene) triphosphate, by mammalian cells in vitro (Journal of Bone and Mineral Research, 1997)
- Randomized, placebo-controlled trial of clodronate in patients with primary operable breast cancer. (Journal of Clinical Oncology, 2002)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Clodronate
- Dichloromethylene Diphosphonate
- Clodronate Disodium
- Dichloromethane Diphosphonate
- Dichloromethanediphosphonic Acid
- Cl2MDP
- Dichloromethylene Biphosphonate
- Dichloromethylenebisphosphonate
- Bonefos
- Clodronate Sodium
- Dichloromethanediphosphonate
-
SMILESC(P(=O)(O)O)(P(=O)(O)O)(Cl)Cl
-
InChIKeyACSIXWWBWUQEHA-UHFFFAOYSA-N
- Pubchem - Clodronic Acid
- Wikipedia - clodronic acid
Clodronic acid (INN) or clodronate disodium (USAN) is a first generation (non-nitrogenous) bisphosphonate. It is an anti-osteoporotic drug approved for the prevention and treatment of osteoporosis in post-menopausal women and men to reduce vertebral fractures, hyperparathyroidism, hypercalcemia in malignancy, multiple myeloma and fracture related pain because of its potent anti-inflammatory and analgesic effects shown as a reduction in inflammatory markers like IL-1, IL-6, and TNF-. While bisphosphonates are shown to be effective in reducing vertebral fractures and pain, their role in improving overall survival remains unclear.
Suppliers
Most-cited Publications
Areas of Application
Safety
Trends
Alternate Names
External Links
Similar Compounds
Methylenediphosphonic acid
(1984-15-2, 63347-66-0)
12 alternate names
3 suppliers
Tc-99m Mdp
(63347-66-0, 80908-09-4)
12 alternate names
3 suppliers
Dimethyl dihydrogen diphosphate
(26644-00-8, 68155-93-1)
12 alternate names
3 suppliers
TEPP
(107-49-3)
12 alternate names
5 safety hazards
3 suppliers
PYROSULFURYL CHLORIDE
(7791-27-7)
12 alternate names
3 suppliers
6419-19-8
(20592-85-2, 6419-19-8)
12 alternate names
3 suppliers
Glyphosate
(1071-83-6)
12 alternate names
3 safety hazards
3 suppliers
Mucochloric acid
(57697-64-0, 87-56-9)
12 alternate names
4 safety hazards
3 suppliers
Mucochloric acid
(57697-64-0, 87-56-9)
12 alternate names
4 safety hazards
3 suppliers
Mucochloric acid
(57697-64-0, 87-56-9)
12 alternate names
4 safety hazards
3 suppliers
carbamoylphosphate
(590-55-6)
12 alternate names
3 suppliers
dichlorvos
(62-73-7)
12 alternate names
8 safety hazards
3 suppliers
TRICHLOROISOCYANURIC ACID
(87-90-1)
12 alternate names
5 safety hazards
3 suppliers
Sulfotep
(3689-24-5)
12 alternate names
6 safety hazards
3 suppliers
Chlorethoxyfos
(54593-83-8)
12 alternate names
3 suppliers
cis-Aconitic acid
(585-84-2, 499-12-7)
12 alternate names
3 suppliers
Trichloromethyl chloroformate
(503-38-8)
12 alternate names
3 suppliers
DIPHOSGENE
(503-38-8)
12 alternate names
3 suppliers
3,3-DICHLORO-1,1,1,2,2-PENTAFLUOROPROPANE
(422-56-0)
12 alternate names
1 safety hazard
3 suppliers
trans-Aconitic acid
(499-12-7, 4023-65-8)
12 alternate names
3 suppliers
Chloroacetic anhydride
(541-88-8)
12 alternate names
3 suppliers
Ammonium L-tartrate
(14307-43-8, 3164-29-2)
12 alternate names
3 suppliers
Chlorosoman
(7040-57-5)
12 alternate names
3 suppliers
naled
(300-76-5)
12 alternate names
3 safety hazards
3 suppliers
HEXACHLOROETHANE
(67-72-1)
12 alternate names
4 safety hazards
3 suppliers
mevinphos
(7786-34-7, 298-01-1)
12 alternate names
6 safety hazards
3 suppliers
beta-Mevinphos
(338-45-4, 7786-34-7, 298-01-1)
12 alternate names
6 safety hazards
3 suppliers
cis-Mevinphos
(7786-34-7, 298-01-1)
12 alternate names
6 safety hazards
3 suppliers
1,1,2,2-Tetrachloro-1,2-difluoroethane
(76-12-0)
12 alternate names
1 safety hazard
3 suppliers
DICHLOROISOCYANURIC ACID
(2782-57-2, 2893-78-9)
12 alternate names
6 safety hazards
3 suppliers
PROPETAMPHOS
(58995-37-2, 31218-83-4)
12 alternate names
4 safety hazards
3 suppliers
Glufosinate-ammonium
(77182-82-2)
12 alternate names
3 safety hazards
3 suppliers
Chlorosulfona
(3064-70-8)
12 alternate names
3 suppliers
TRICHLOROACETYL CHLORIDE
(76-02-8)
12 alternate names
3 suppliers
phosphocreatine
(67-07-2)
12 alternate names
3 suppliers
2-hydroxyglutaric acid
(2889-31-8)
12 alternate names
3 suppliers
(2R)-2-hydroxypentanedioic acid
(2889-31-8)
12 alternate names
3 suppliers
67-07-2
(67-07-2)
12 alternate names
3 suppliers
Sparfosic acid
(51321-79-0)
12 alternate names
3 suppliers
D-greenwald ester
(138-81-8, 14438-19-8)
12 alternate names
3 suppliers
SOMAN
(96-64-0)
12 alternate names
3 suppliers
Tx 60
(50782-69-9, 65167-63-7, 65167-64-8)
12 alternate names
3 suppliers
CHLOROPICRIN
(76-06-2)
12 alternate names
7 safety hazards
3 suppliers
2,4,6-TRICHLOROPHENOL
(88-06-2)
12 alternate names
4 safety hazards
3 suppliers
DICROTOPHOS
(141-66-2, 3735-78-2)
12 alternate names
5 safety hazards
3 suppliers
MONOCROTOPHOS
(6923-22-4, 919-44-8, 2157-98-4)
12 alternate names
4 safety hazards
3 suppliers
ethion
(563-12-2)
12 alternate names
3 safety hazards
3 suppliers
acephate
(30560-19-1, 115096-11-2)
12 alternate names
4 safety hazards
3 suppliers
Dichlorprop
(120-36-5, 15165-67-0)
12 alternate names
5 safety hazards
3 suppliers
OXYDEMETON-METHYL
(301-12-2)
12 alternate names
7 safety hazards
3 suppliers
OMETHOATE
(1113-02-6)
12 alternate names
2 safety hazards
3 suppliers
MONOSODIUM GLUTAMATE
(21932-17-2, 142-47-2)
12 alternate names
3 suppliers
2,2-Dichloropropionic acid
(75-99-0)
12 alternate names
4 safety hazards
3 suppliers
OXAMYL
(23135-22-0)
12 alternate names
4 safety hazards
3 suppliers
triacetin
(102-76-1)
12 alternate names
3 suppliers
Vydate
(23135-22-0)
12 alternate names
4 safety hazards
3 suppliers
VAMIDOTHION
(2275-23-2)
12 alternate names
4 safety hazards
3 suppliers
SCHRADAN
(152-16-9)
12 alternate names
4 safety hazards
3 suppliers
16079-88-2
(16079-88-2)
12 alternate names
3 suppliers
2,3,6-TRICHLOROPHENOL
(933-75-5)
12 alternate names
3 suppliers
6440-58-0
(6440-58-0)
12 alternate names
3 suppliers
CAS Directory
