| Weight | 329.871 g/mol |
|---|---|
| Formula | C20H24ClNO |
| Hydrogen Acceptors | 2 |
| Hydrogen Donors | 0 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 6 |
cloperastine (3703-76-2)
1-(2-((4-chloro-alpha-phenylbenzyl)oxy)ethyl)piperidine · cloperastine hydrochloride
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- Simultaneous quantitation of paracetamol, caffeine, pseudoephedrine, chlorpheniramine and cloperastine in human plasma by liquid chromatography-tandem mass spectrometry. (Journal of Pharmaceutical and Biomedical Analysis, 2010)
- Pharmacological and clinical overview of cloperastine in treatment of cough (Therapeutics and Clinical Risk Management, 2011)
- Effects of solid-state reaction between paracetamol and cloperastine hydrochloride on the pharmaceutical properties of their preparations (International Journal of Pharmaceutics, 2007)
- Development of chromatographic methods for the determination of genotoxic impurities in cloperastine fendizoate. (Journal of Pharmaceutical and Biomedical Analysis, 2012)
- Ameliorating effects of cloperastine on dysfunction of the urinary bladder caused by cerebral infarction in conscious rats (Canadian Journal of Physiology and Pharmacology, 2009)
- Effects of the Antitussive Drug Cloperastine on Ventricular Repolarization in Halothane-Anesthetized Guinea Pigs (Journal of Pharmacological Sciences, 2012)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - 1-(2-((4-chloro-alpha-phenylbenzyl)oxy)ethyl)piperidine
- cloperastine hydrochloride
-
SMILESC1CCN(CC1)CCOC(C2=CC=CC=C2)C3=CC=C(C=C3)Cl
-
InChIKeyFLNXBVJLPJNOSI-UHFFFAOYSA-N
- Pubchem - cloperastine
- Wikipedia - cloperastine
Cloperastine (INN) or cloperastin, also known as cloperastine hydrochloride (JAN) (brand names Hustazol, Nitossil, Seki) and cloperastine fendizoate (or hybenzoate), is an antitussive and antihistamine that is marketed as a cough suppressant in Japan, Hong Kong, and in some European countries. It was first introduced in 1972 in Japan, and then in Italy in 1981. The precise mechanism of action of cloperastine is not fully clear, but several different biological activities have been identified for the drug, of which include: ligand of the 1 receptor (Ki = 20 nM) (likely an agonist), GIRK channel blocker (described as "potent"), antihistamine (Ki = 3.8 nM for the H1 receptor), and anticholinergic.
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