Weight | 767.541 g/mol |
---|---|
Formula | C21H36N7O16P3S |
Hydrogen Acceptors | 18 |
Hydrogen Donors | 10 |
Aromatic Rings | 2 |
Rotatable Bonds | 18 |
coenzyme A (85-61-0)
CoA · CoASH
Score:
#872 in Biochemistry
,
#2339 in Biology
,
#2900 in Chemistry
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- Upregulation of Endothelial Nitric Oxide Synthase by HMG CoA Reductase Inhibitors (Circulation, 1998)
- [1] Citrate synthase. [EC 4.1.3.7. Citrate oxaloacetate-lyase (CoA-acetylating)] (Methods in Enzymology, 1969)
- The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals (Nature Medicine, 2000)
- HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway (Journal of Clinical Investigation, 2001)
- The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease (Nature, 2002)
- Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase (Proceedings of the National Academy of Sciences of the United States of America, 1998)
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Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - CoA
- CoASH
-
SMILESCC(C)(COP(=O)(O)OP(=O)(O)OCC1C(C(C(O1)N2C=NC3=C2N=CN=C3N)O)OP(=O)(O)O)C(C(=O)NCCC(=O)NCCS)O
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InChIKeyRGJOEKWQDUBAIZ-UHFFFAOYSA-N
- Pubchem - coenzyme A
- Wikipedia - Coenzyme A
Coenzyme A (CoA, CoASH, or HSCoA) is a coenzyme, notable for its role in the synthesis and oxidation of fatty acids, and the oxidation of pyruvate in the citric acid cycle. All genomes sequenced to date encode enzymes that use coenzyme A as a substrate, and around 4% of cellular enzymes use it (or a thioester, such as acetyl-CoA) as a substrate. In humans, CoA biosynthesis requires cysteine, pantothenate, and adenosine triphosphate (ATP).
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