| Weight | 389.886 g/mol |
|---|---|
| Formula | C14H16ClN3O4S2 |
| Hydrogen Acceptors | 5 |
| Hydrogen Donors | 3 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 2 |
cyclothiazide (2259-96-3)
Score:
#422 in Neuroscience
,
#1927 in Biology
,
#2338 in Chemistry
"What do you need help with?"
LabBot
- Sigma-Aldrich - Search for cyclothiazide
- Fisher Scientific - Search for cyclothiazide
- TCI - Search for cyclothiazide
- Selective modulation of desensitization at AMPA versus kainate receptors by cyclothiazide and concanavalin A (Neuron, 1993)
- Hippocampal neurons exhibit cyclothiazide-sensitive rapidly desensitizing responses to kainate (The Journal of Neuroscience, 1993)
- AMPA Receptor Flip/Flop Mutants Affecting Deactivation, Desensitization, and Modulation by Cyclothiazide, Aniracetam, and Thiocyanate (The Journal of Neuroscience, 1996)
- Cyclothiazide differentially modulates desensitization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor splice variants. (Molecular Pharmacology, 1994)
- Differential modulation by cyclothiazide and concanavalin A of desensitization at native alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid- and kainate-preferring glutamate receptors. (Molecular Pharmacology, 1993)
- Interactions among GYKI-52466, cyclothiazide, and aniracetam at recombinant AMPA and kainate receptors. (Molecular Pharmacology, 1995)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESC1C2CC(C1C=C2)C3NC4=CC(=C(C=C4S(=O)(=O)N3)S(=O)(=O)N)Cl
-
InChIKeyBOCUKUHCLICSIY-UHFFFAOYSA-N
- Pubchem - cyclothiazide
- Wikipedia - cyclothiazide
Cyclothiazide (Anhydron, Acquirel, Doburil, Fluidil, Renazide, Tensodiural, Valmiran) is a benzothiadiazide (thiazide) diuretic and antihypertensive that was originally introduced in the United States in 1963 by Eli Lilly and was subsequently also marketed in Europe and Japan. Related drugs include diazoxide, hydrochlorothiazide, and chlorothiazide. In 1993, it was discovered that cyclothiazide is a positive allosteric modulator of the AMPA and kainate receptors, capable of reducing or essentially eliminating rapid desensitization of the former receptor, and potentiating AMPA-mediated glutamate currents by as much as 18-fold at the highest concentration tested (100 M).
Suppliers
Most-cited Publications
Areas of Application
Safety
Trends
Alternate Names
External Links
Similar Compounds
4,4'-oxydibenzenesulfonohydrazide
(80-51-3)
1 alternate name
3 safety hazards
3 suppliers
Salbutamol sulfate
(51022-70-9)
1 alternate name
3 suppliers
cyclic gmp
(7665-99-8)
1 alternate name
3 suppliers
Progabide
(62666-20-0)
1 alternate name
3 suppliers
Progabide
(62666-20-0, 104880-78-6)
1 alternate name
3 suppliers
Progabide
(62666-20-0)
1 alternate name
3 suppliers
Methenamine hippurate
(5714-73-8)
1 alternate name
3 suppliers
pioglitazone hydrochloride
(112529-15-4)
1 alternate name
3 suppliers
N-Methyl-p-aminophenol sulfate
(55-55-0)
1 alternate name
3 safety hazards
3 suppliers
Epinastine hydrochloride
(108929-04-0)
1 alternate name
3 suppliers
tiapride
(51012-32-9)
1 alternate name
3 suppliers
DIPHENYLAMINE SULFATE
(587-84-8, 56961-69-4)
1 alternate name
3 suppliers
Nicotine bitartrate
(65-31-6)
1 alternate name
3 suppliers
XIPAMIDE
(14293-44-8)
1 alternate name
3 suppliers
methoxychlor
(72-43-5)
1 alternate name
3 safety hazards
3 suppliers
DICOFOL
(115-32-2)
1 alternate name
6 safety hazards
3 suppliers
Crufomate
(299-86-5)
1 alternate name
6 safety hazards
3 suppliers
Acebutolol hydrochloride
(34381-68-5)
1 alternate name
3 suppliers
citrinin
(518-75-2)
1 alternate name
3 suppliers
Ketorolac tromethamine
(74103-07-4)
1 alternate name
3 suppliers
Sotalol hydrochloride
(959-24-0)
1 alternate name
3 suppliers
Fingolimod hydrochloride
(162359-56-0)
1 alternate name
3 suppliers
ZERANOL
(26538-44-3, 55331-29-8)
1 alternate name
3 suppliers
Sultopride
(53583-79-2)
1 alternate name
3 suppliers
Eletriptan hydrobromide
(177834-92-3)
1 alternate name
3 suppliers
HEMATOXYLIN
(517-28-2, 17647-60-8)
1 alternate name
3 suppliers
Haematoxylin
(517-28-2)
1 alternate name
3 suppliers
HEMATOXYLIN
(517-28-2)
1 alternate name
3 suppliers
Statobex
(50-58-8)
1 alternate name
3 suppliers
4-CHLORO-3-NITROBENZENESULFONAMIDE
(97-09-6)
1 alternate name
3 suppliers
DICLAZURIL
(101831-37-2)
1 alternate name
3 suppliers
Sodium 4-decylbenzenesulfonate
(2627-06-7)
1 alternate name
3 suppliers
Didp
(26575-15-5, 26761-40-0, 890-38-0)
1 alternate name
3 suppliers
FLUMETHIAZIDE
(148-56-1)
1 alternate name
3 suppliers
N-Acetylsulfanilyl chloride
(121-60-8)
1 alternate name
3 suppliers
Clofenotane
(50-29-3)
1 alternate name
4 safety hazards
3 suppliers
aldrin
(124-96-9, 309-00-2, 465-73-6)
1 alternate name
8 safety hazards
3 suppliers
aldrin
(309-00-2)
1 alternate name
8 safety hazards
3 suppliers
aldrin
(309-00-2)
1 alternate name
8 safety hazards
3 suppliers
aldrin
(309-00-2)
1 alternate name
8 safety hazards
3 suppliers
aldrin
(309-00-2)
1 alternate name
8 safety hazards
3 suppliers
Hydromorphone hydrochloride
(71-68-1)
1 alternate name
3 suppliers
4,4'-Diphenylmethane diisocyanate
(26447-40-5, 101-68-8, 9016-87-9)
1 alternate name
5 safety hazards
3 suppliers
aldrin
(309-00-2, 465-73-6)
1 alternate name
8 safety hazards
3 suppliers
CAS Directory
