| Weight | 293.37 g/mol |
|---|---|
| Formula | C18H19N3O |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 4 |
Daca (89459-25-6)
Score:
#2742 in Biochemistry
,
#5180 in Biology
,
#6780 in Chemistry
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- From amsacrine to DACA (N-[2-(dimethylamino)ethyl]acridine-4-carboxamide): Selectivity for topoisomerases I and II among acridine derivatives (European Journal of Cancer, 1996)
- The gene bolA regulates dacA (PBP5), dacC (PBP6) and ampC (AmpC), promoting normal morphology in Escherichia coli (Molecular Microbiology, 2002)
- Major groove binding and 'DNA-induced' fit in the intercalation of a derivative of the mixed topoisomerase I/II poison N-(2-(dimethylamino)ethyl)acridine-4-carboxamide (DACA) into DNA: X-ray structure complexed to d(CG(5-BrU)ACG)2 at 1.3-A resolution. (Journal of Medicinal Chemistry, 1999)
- Defective and plaque-forming lambda transducing bacteriophage carrying penicillin-binding protein-cell shape genes: genetic and physical mapping and identification of gene products from the lip-dacA-rodA-pbpA-leuS region of the Escherichia coli chromosome. (Journal of Bacteriology, 1980)
- Genes encoding two lipoproteins in the leuS-dacA region of the Escherichia coli chromosome. (Journal of Bacteriology, 1987)
- Mycobacterium tuberculosis Rv3586 (DacA) Is a Diadenylate Cyclase That Converts ATP or ADP into c-di-AMP (PLOS ONE, 2012)
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SMILESCN(C)CCNC(=O)C1=CC=CC2=CC3=CC=CC=C3N=C21
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- Pubchem - Daca
- Wikipedia - acridine carboxamide
Acridine carboxamide is an chemotherapy agent that is being studied in the treatment of cancer. It belongs to the family of drugs called topoisomerase inhibitors. While the agent was well tolerated in Phase II clinical trials, it did not show efficacy when tested against various types of cancers.
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