| Weight | 410.426 g/mol |
|---|---|
| Formula | C22H22N2O6 |
| Hydrogen Acceptors | 7 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 9 |
Darusentan (171714-84-4)
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- Long-term effects of darusentan on left-ventricular remodelling and clinical outcomes in the EndothelinA Receptor Antagonist Trial in Heart Failure (EARTH): randomised, double-blind, placebo-controlled trial (The Lancet, 2004)
- Darusentan: An effective endothelinA receptor antagonist for treatment of hypertension (American Journal of Hypertension, 2002)
- Divergent Results Using Clinic and Ambulatory Blood Pressures: Report of a Darusentan-Resistant Hypertension Trial (Hypertension, 2010)
- Efficacy and safety of darusentan in patients with resistant hypertension: results from a randomized, double-blind, placebo-controlled dose-ranging study. (Journal of Clinical Hypertension, 2007)
- Evaluation of the endothelin receptor antagonists ambrisentan, darusentan, bosentan, and sitaxsentan as substrates and inhibitors of hepatobiliary transporters in sandwich-cultured human hepatocytes. (Canadian Journal of Physiology and Pharmacology, 2010)
- Up-regulated inflammatory factors endothelin, NFB, TNF and iNOS involved in exaggerated cardiac arrhythmias in L-thyroxine-induced cardiomyopathy are suppressed by darusentan in rats (Life Sciences, 2006)
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Predict GHS Hazards for Any Chemical in silico.
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- Pubchem - Darusentan
- Wikipedia - darusentan
Darusentan (LU-135252; HMR-4005) is an endothelin receptor antagonist. Gilead Colorado, a subsidiary of Gilead Sciences, under license from Abbott Laboratories, is developing darusentan for the potential treatment of uncontrolled hypertension. In June 2003, Myogen licensed the compound from Abbott for its application in the cancer field.
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