Weight | 175.235 g/mol |
---|---|
Formula | C10H13N3 |
Hydrogen Acceptors | 1 |
Hydrogen Donors | 2 |
Aromatic Rings | 1 |
Rotatable Bonds | 0 |
Debrisoquine (1131-64-2)
Debrisoquin · Tendor
Score:
#678 in Neuroscience
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#3014 in Biology
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#3766 in Chemistry
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- POLYMORPHIC HYDROXYLATION OF DEBRISOQUINE IN MAN (The Lancet, 1977)
- Characterization of the common genetic defect in humans deficient in debrisoquine metabolism. (Nature, 1988)
- Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine. (Proceedings of the National Academy of Sciences of the United States of America, 1993)
- A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population. (Journal of Medical Genetics, 1980)
- Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populations. (Clinical Pharmacology & Therapeutics, 1985)
- Genotyping of poor metabolisers of debrisoquine by allele-specific PCR amplification (The Lancet, 1990)
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Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Debrisoquin
- Tendor
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SMILESC1CN(CC2=CC=CC=C21)C(=N)N
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InChIKeyJWPGJSVJDAJRLW-UHFFFAOYSA-N
- Pubchem - Debrisoquine
- Wikipedia - debrisoquin
Debrisoquine is a derivative of guanidine. It is an antihypertensive drug similar to guanethidine. Debrisoquine is frequently used for phenotyping the CYP2D6 enzyme, a drug metabolizing enzyme.
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Synthesis
CHEMBL21503
+
Reactant
(Chan-Lam coupling reaction)
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