| Weight | 294.442 g/mol |
|---|---|
| Formula | C20H26N2 |
| Hydrogen Acceptors | 2 |
| Hydrogen Donors | 0 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 4 |
Dimetacrine (4757-55-5)
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- STUDIES ON THE ULTRASTRUCTURAL DISTRIBUTION OF H 3 -DIMETACRINE IN RAT CEREBRAL CORTEX (Japanese Journal of Pharmacology, 1972)
- Binding of H3-imipramine, H3-dimetacrine and S35-chlorpromazine to synaptosomes. (Japanese Journal of Pharmacology, 1978)
- COMPARISON OF CARDIOVASCULAR TOXICITIES INDUCED BY DIMETACRINE, IMIPRAMINE AND AMITRIPTYLINE IN ISOLATED GUINEA PIG ATRIA AND ANESTHETIZED DOGS (Japanese Journal of Pharmacology, 1974)
- Distribution of H3-dimetacrine in rat cerebral cortex by electron microscopic autoradiography. (Cellular and Molecular Life Sciences, 1976)
- THE PHARMACOLOGICAL STUDIES ON DIMETACRINE (Japanese Journal of Pharmacology, 1970)
- Kinetics and mechanism of oxidation of dimetacrine, imipramine and phenothiazine drugs. (Pharmaceutica Acta Helvetiae, 1977)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC1(C2=CC=CC=C2N(C3=CC=CC=C31)CCCN(C)C)C
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- Pubchem - Dimetacrine
- Wikipedia - dimetacrine
Dimetacrine (brand names Istonil, Istonyl, Linostil, Miroistonil), also known as dimethacrine and acripramine, is a tricyclic antidepressant (TCA) used in Europe and formerly in Japan for the treatment of depression. It has imipramine-like effects; though, in a double-blind clinical trial against imipramine, dimetacrine was found to have lower efficacy in comparison and produced more weight loss and abnormal liver tests. Little is known about the pharmacology of dimetacrine, but it can be inferred that it acts in a similar manner to other TCAs.
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