Weight | 414.63 g/mol |
---|---|
Formula | C27H42O3 |
Hydrogen Acceptors | 3 |
Hydrogen Donors | 1 |
Aromatic Rings | 0 |
Rotatable Bonds | 0 |
DIOSGENIN (512-04-9)
Score:
#2729 in Biochemistry
,
#5170 in Biology
,
#6754 in Chemistry
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- Sigma-Aldrich - DIOSGENIN49.80 - 553.00 USD
- Fisher Scientific - Search for DIOSGENIN
- TCI - Search for DIOSGENIN
- Diosgenin, a Steroid Saponin of Trigonella foenum graecum (Fenugreek), Inhibits Azoxymethane-Induced Aberrant Crypt Foci Formation in F344 Rats and Induces Apoptosis in HT-29 Human Colon Cancer Cells (Cancer Epidemiology, Biomarkers & Prevention, 2004)
- Detection of Proto-type Compounds of Diosgenin-and Other Spirostanol-Glycosides (Chemical & Pharmaceutical Bulletin, 1968)
- A plant steroid, diosgenin, induces apoptosis, cell cycle arrest and COX activity in osteosarcoma cells (FEBS Letters, 2001)
- Diosgenin inhibits osteoclastogenesis, invasion, and proliferation through the downregulation of Akt, I kappa B kinase activation and NF-kappa B-regulated gene expression. (Oncogene, 2006)
- Antioxidative and Hypolipidemic Effects of Diosgenin, a Steroidal Saponin of Yam (Dioscorea spp.), on High-Cholesterol Fed Rats (Bioscience, Biotechnology, and Biochemistry, 2007)
- Induction of antiproliferative effect by diosgenin through activation of p53, release of apoptosis-inducing factor (AIF) and modulation of caspase-3 activity in different human cancer cells (Cell Research, 2004)
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Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC1CCC2(C(C3C(O2)CC4C3(CCC5C4CC=C6C5(CCC(C6)O)C)C)C)OC1
-
InChIKeyWQLVFSAGQJTQCK-UHFFFAOYSA-N
- Pubchem - DIOSGENIN
- Wikipedia - diosgenin
Diosgenin, a phytosteroid sapogenin, is the product of hydrolysis by acids, strong bases, or enzymes of saponins, extracted from the tubers of Dioscorea wild yam, such as the Kokoro. The sugar-free (aglycone) product of such hydrolysis, diosgenin is used for the commercial synthesis of cortisone, pregnenolone, progesterone, and other steroid products.
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