| Weight | 296.552 g/mol |
|---|---|
| Formula | C10H20N2S4 |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 0 |
| Aromatic Rings | 0 |
| Rotatable Bonds | 4 |
Disulfiram (97-77-8)
Antabuse · Tetraethylthiuram Disulfide · Antabus
Score:
#52 in Neuroscience
,
#257 in Biology
,
#268 in Chemistry
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- Disulfiram Treatment of Alcoholism: A Veterans Administration Cooperative Study (JAMA, 1986)
- ALCOHOLISM TREATMENT BY DISULFIRAM AND COMMUNITY REINFORCEMENT THERAPY (Journal of Behavior Therapy and Experimental Psychiatry, 1982)
- Efficacy of Disulfiram and Cognitive Behavior Therapy in Cocaine-Dependent Outpatients: A Randomized Placebo-Controlled Trial (Archives of General Psychiatry, 2004)
- Disulfiram treatment of alcoholism. (British Journal of Psychiatry, 1992)
- Treatment of cocaine and alcohol dependence with psychotherapy and disulfiram (Addiction, 1998)
- Inhibition of dopamine- -hydroxylase by disulfiram (Life Sciences, 1964)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - H302: Harmful if swallowed
Warning Acute toxicity, oral - Category 4 - H303: May be harmful if swallowed
Warning Acute toxicity, oral - Category 5 - H361: Suspected of damaging fertility or the unborn child
Warning Reproductive toxicity - Category 2 - H372: Causes damage to organs through prolonged or repeated exposure
Danger Specific target organ toxicity, repeated exposure - Category 1 - H373: Causes damage to organs through prolonged or repeated exposure
Warning Specific target organ toxicity, repeated exposure - Category 2 - H410: Very toxic to aquatic life with long lasting effects
Warning Hazardous to the aquatic environment, long-term hazard - Category 1 - Antabuse
- Tetraethylthiuram Disulfide
- Antabus
- Esperal
- Anticol
- Tetraethylthioperoxydicarbonic Diamide, ((H2N)C(S))2S2
- Dicupral
- Teturam
- Alcophobin
- Bis(diethylthiocarbamoyl) Disulfide
-
SMILESCCN(CC)C(=S)SSC(=S)N(CC)CC
-
InChIKeyAUZONCFQVSMFAP-UHFFFAOYSA-N
- Pubchem - Disulfiram
- Wikipedia - disulfiram
Disulfiram (sold under the trade names Antabuse and Antabus) is a drug used to support the treatment of chronic alcoholism by producing an acute sensitivity to ethanol (drinking alcohol). Disulfiram works by inhibiting the enzyme acetaldehyde dehydrogenase, which means that many of the effects of a "hangover" are felt immediately after alcohol is consumed. "Disulfiram plus alcohol, even small amounts, produce flushing, throbbing in head and neck, throbbing headache, respiratory difficulty, nausea, copious vomiting, sweating, thirst, chest pain, palpitation, dyspnea, hyperventilation, tachycardia, hypotension, syncope, marked uneasiness, weakness, vertigo, blurred vision, and confusion.
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Most-cited Publications
Areas of Application
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Alternate Names
Estimated Properties
| Density | 1.25 g/cm3 | EPA T.E.S.T. |
|---|---|---|
| Flash Point | 159.25 C | EPA T.E.S.T. |
| Water Solubility | 11.75 mg/L | EPA T.E.S.T. |
External Links
Synthesis
Ethylboronic acid
+
Reactant
(Chan-Lam coupling reaction)
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Disulfiram
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