| Weight | 314.341 g/mol |
|---|---|
| Formula | C17H18N2O4 |
| Hydrogen Acceptors | 5 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 4 |
DMCM (82499-00-1)
Score:
#1214 in Neuroscience
,
#5207 in Biology
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- DMCM: a potent convulsive benzodiazepine receptor ligand. (European Journal of Pharmacology, 1983)
- The dorsal raphe nucleus is a site of action mediating the behavioral effects of the benzodiazepine receptor inverse agonist DMCM. (Behavioral Neuroscience, 1995)
- The benzodiazepine inverse agonist DMCM as an unconditional stimulus for fear-induced analgesia: implications for the role of GABAA receptors in fear-related behavior. (Behavioral Neuroscience, 1992)
- Binding of [3H]DMCM, a Convulsive Benzodiazepine Ligand, to Rat Brain Membranes: Preliminary Studies (Journal of Neurochemistry, 1983)
- Aggravation of DMCM-induced seizure by nitric oxide synthase inhibitors in mice. (Life Sciences, 1997)
- Effects of Antiepileptic Drugs on GABA Responses and on Reduction of GABA Responses by PTZ and DMCM on Mouse Neurons in Cell Culture (Epilepsia, 1989)
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SMILESCCC1=C2C3=CC(=C(C=C3NC2=CN=C1C(=O)OC)OC)OC
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InChIKeyGADIKQPUNWAMEB-UHFFFAOYSA-N
- Pubchem - DMCM
- Wikipedia - methyl 6,7-dimethoxy-4-ethyl--carboline-3-carboxylate
DMCM (methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate) is a drug from the beta-carboline family. It acts as a negative allosteric modulator of GABAA receptors, meaning that it causes the opposite effects to the benzodiazepine class of drugs. As such, DMCM has anxiogenic and convulsant properties, and is used in scientific research to induce anxiety so that new anxiolytic medications can be tested, and to produce convulsions so that anticonvulsant medications can be tested.
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