| Weight | 356.51 g/mol |
|---|---|
| Formula | C22H32N2O2 |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 4 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 13 |
Dopexamine (86197-47-9)
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- Dopexamine: a novel agonist at peripheral dopamine receptors and 2-adrenoceptors (British Journal of Pharmacology, 1985)
- Protecting the gut and the liver in the critically ill: effects of dopexamine. (Critical Care Medicine, 1994)
- Abnormalities of Gastric Mucosal Oxygenation in Septic Shock: Partial Responsiveness to Dopexamine (American Journal of Respiratory and Critical Care Medicine, 1998)
- Effect of dopexamine on outcome after major abdominal surgery: A prospective, randomized, controlled multicenter study (Critical Care Medicine, 2000)
- Cardiovascular Pharmacology of Dopexamine in Low Output Congestive Heart Failure (American Journal of Cardiology, 1988)
- Dopexamine increases splanchnic blood flow but decreases gastric mucosal pH in severe septic patients treated with dobutamine (Critical Care Medicine, 1999)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESC1=CC=C(C=C1)CCNCCCCCCNCCC2=CC(=C(C=C2)O)O
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InChIKeyRYBJORHCUPVNMB-UHFFFAOYSA-N
- Pubchem - Dopexamine
- Wikipedia - dopexamine
Dopexamine is a synthetic analogue of dopamine that is administered intravenously in hospitals to reduce exacerbations of heart failure and to treat heart failure following cardiac surgery. It is not used often, as more established drugs like epinephrine, dopamine, dobutamine, norepinephrine, and levosimendan work as well. It works by stimulating beta-2 adrenergic receptors and peripheral dopamine receptor D1 and dopamine receptor D2.
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Synthesis
Pyrocatechol
+
Reactant
(Friedel-Crafts alkylation)
N'-(2-Phenylethyl)hexane-1,6-diamine
+
Reactant
(Alkylation of primary amines)
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