| Weight | 295.451 g/mol |
|---|---|
| Formula | C19H21NS |
| Hydrogen Acceptors | 2 |
| Hydrogen Donors | 0 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 3 |
Dothiepin (113-53-1, 25627-38-7)
Prothiaden · Dothiepin Hydrochloride · Dosulepin
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- Greater toxicity in overdose of dothiepin than of other tricyclic antidepressants. (The Lancet, 1994)
- A comparative study of acute and subchronic effects of dothiepin, fluoxetine and placebo on psychomotor and actual driving performance. (British Journal of Clinical Pharmacology, 1995)
- Risk of suicide during treatment with venlafaxine, citalopram, fluoxetine, and dothiepin: retrospective cohort study (BMJ, 2007)
- Cost Utility of Maintenance Treatment of Recurrent Depression with Sertraline Versus Episodic Treatment with Dothiepin (PharmacoEconomics, 1994)
- Double-blind study of dothiepin versus placebo in the treatment of primary fibromyalgia syndrome. (Journal of International Medical Research, 1987)
- A randomised, double-blind, parallel-group comparison of venlafaxine and dothiepin in geriatric patients with major depression. (International Journal of Clinical Practice, 1997)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Prothiaden
- Dothiepin Hydrochloride
- Dosulepin
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SMILESCN(C)CCC=C1C2=CC=CC=C2CSC3=CC=CC=C31
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InChIKeyPHTUQLWOUWZIMZ-UHFFFAOYSA-N
- Pubchem - Dothiepin
- Wikipedia - dothiepin
Dosulepin, also known as dothiepin and sold under the brand name Prothiaden among others, is a tricyclic antidepressant (TCA) which is used in the treatment of depression. Dosulepin was once the most frequently prescribed antidepressant in the United Kingdom, but it is no longer widely used due to its relatively high toxicity in overdose without therapeutic advantages over other TCAs. It acts as a serotoninnorepinephrine reuptake inhibitor (SNRI) and also has other activities including antihistamine, antiadrenergic, antiserotonergic, anticholinergic, and sodium channel-blocking effects.
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