| Weight | 477.435 g/mol |
|---|---|
| Formula | C14H17BrN6O2S3 |
| Hydrogen Acceptors | 7 |
| Hydrogen Donors | 3 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 9 |
Ebrotidine (100981-43-9)
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- Induction of tumor necrosis factor- and apoptosis in gastric mucosal injury by indomethacin : Effect of omeprazole and ebrotidine (Scandinavian Journal of Gastroenterology, 1997)
- Acute liver injury associated with the use of ebrotidine, a new H2-receptor antagonist (Journal of Hepatology, 1999)
- Comparative study of the safety and efficacy of ebrotidine versus ranitidine and placebo in the prevention of piroxicam-induced gastroduodenal lesions. (Drug Research, 1997)
- Mechanism of ebrotidine protection against gastric mucosal injury induced by ethanol (General Pharmacology-the Vascular System, 1992)
- Rapid progression to liver cirrhosis of toxic hepatitis due to ebrotidine (Journal of Hepatology, 1999)
- Gastric mucosal EGF and PDGF receptor expression with ulcer healing by ebrotidine. (The American Journal of Gastroenterology, 1994)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESC1=CC(=CC=C1S(=O)(=O)NC=NCCSCC2=CSC(=N2)N=C(N)N)Br
-
InChIKeyZQHFZHPUZXNPMF-UHFFFAOYSA-N
- Pubchem - Ebrotidine
- Wikipedia - ebrotidine
Ebrotidine is an H2 receptor antagonist with gastroprotective activity against ethanol-, aspirin- or stress-induced gastric mucosal damage. The antisecretory properties of ebrotidine are similar to those of ranitidine, and approximately 10-fold greater than those of cimetidine. Ebrotidine has anti-Helicobacter pylori activity via inhibition of the urease enzyme and the proteolytic and mucolytic activities of the bacterium.
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Synthesis
Reactant
+
2-[4-(2-aminoethylsulfanylmethyl)-1,3-thiazol-2-yl]guanidine
(Imine formation from aldehyde)
4-Bromobenzenesulfonyl chloride
+
Reactant
(Sulfonamide)
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