| Weight | 348.397 g/mol |
|---|---|
| Formula | C18H22F2N4O |
| Hydrogen Acceptors | 5 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 5 |
EFINACONAZOLE (164650-44-6)
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- Efinaconazole 10% solution in the treatment of toenail onychomycosis: Two phase III multicenter, randomized, double-blind studies (Journal of The American Academy of Dermatology, 2013)
- Comparison of In Vitro Antifungal Activities of Efinaconazole and Currently Available Antifungal Agents against a Variety of Pathogenic Fungi Associated with Onychomycosis (Antimicrobial Agents and Chemotherapy, 2013)
- Mechanism of Action of Efinaconazole, a Novel Triazole Antifungal Agent (Antimicrobial Agents and Chemotherapy, 2013)
- The Low Keratin Affinity of Efinaconazole Contributes to Its Nail Penetration and Fungicidal Activity in Topical Onychomycosis Treatment (Antimicrobial Agents and Chemotherapy, 2014)
- Safety and pharmacokinetics of efinaconazole 10% solution in healthy volunteers and patients with severe onychomycosis. (Journal of Drugs in Dermatology, 2013)
- An enantioselective synthesis of the key intermediate for triazole antifungal agents; application to the catalytic asymmetric synthesis of efinaconazole (Jublia). (Journal of Organic Chemistry, 2014)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC(C(CN1C=NC=N1)(C2=C(C=C(C=C2)F)F)O)N3CCC(=C)CC3
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InChIKeyNFEZZTICAUWDHU-UHFFFAOYSA-N
- Pubchem - EFINACONAZOLE
- Wikipedia - efinaconazole
Efinaconazole (trade names Jublia and Clenafin) is a triazole antifungal. It is approved for use in Canada and the USA, JAPAN as a 10% topical solution for the treatment of onychomycosis (fungal infection of the nail). Efinaconazole acts as a 14-demethylase inhibitor.
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