| Weight | 347.861 g/mol |
|---|---|
| Formula | C20H23ClFNO |
| Hydrogen Acceptors | 2 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 5 |
Eliprodil (119431-25-3)
Score:
#1103 in Neuroscience
,
#4797 in Biology
,
#6122 in Chemistry
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- Antidepressant-like actions of the polyamine site NMDA antagonist, eliprodil (SL-82.0715) (Pharmacology, Biochemistry and Behavior, 1995)
- Prevention by eliprodil (SL 82.0715) of traumatic brain damage in the rat. Existence of a large (18h) therapeutic window (Brain Research, 1993)
- Microbiological transformations. Part 45: A green chemistry preparative scale synthesis of enantiopure building blocks of Eliprodil: elaboration of a high substrate concentration epoxide hydrolase-catalyzed hydrolytic kinetic resolution process (Tetrahedron, 2001)
- The effects of ifenprodil and eliprodil on voltage-dependent Ca2+ channels and in gerbil global cerebral ischaemia (European Journal of Pharmacology, 1996)
- Antagonist properties of eliprodil and other NMDA receptor antagonists at rat NR1A/NR2A and NR1A/NR2B receptors expressed in Xenopus oocytes (Neuroscience Letters, 1997)
- Neuroprotective effects of eliprodil in retinal excitotoxicity and ischemia. (Investigative Ophthalmology & Visual Science, 1999)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESC1CN(CCC1CC2=CC=C(C=C2)F)CC(C3=CC=C(C=C3)Cl)O
-
InChIKeyGGUSQTSTQSHJAH-UHFFFAOYSA-N
- Pubchem - Eliprodil
- Wikipedia - eliprodil
Eliprodil (codenamed SL-82.0715) is a NMDA antagonist drug candidate that failed a Phase III clinical trial for the treatment of acute ischemic stroke in 1996, sponsored by Synthlabo Recherche. NMDA receptors are a key component in mediating glutamate-induced excitotoxicity, and it is believed that NMDA antagonists would be neuroprotective after a stroke or other traumatic brain injury. After a traumatic brain injury, neurons become deprived of glucose and oxygen.
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Eliprodil
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