Weight | 376.416 g/mol |
---|---|
Formula | C21H20N4O3 |
Hydrogen Acceptors | 5 |
Hydrogen Donors | 3 |
Aromatic Rings | 3 |
Rotatable Bonds | 6 |
Entinostat (209783-80-2)
MS 275 · MS-27-275 · N-(2-aminophenyl)-4-(N-(pyridin-3-ylmethoxycarbonyl)aminomethyl)benzamide
Score:
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- A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors. (Proceedings of the National Academy of Sciences of the United States of America, 1999)
- The Histone Deacetylase Inhibitor MS-275 Promotes Differentiation or Apoptosis in Human Leukemia Cells through a Process Regulated by Generation of Reactive Oxygen Species and Induction of p21CIP1/WAF1 1 (Cancer Research, 2003)
- Phase I and Pharmacokinetic Study of MS-275, a Histone Deacetylase Inhibitor, in Patients With Advanced and Refractory Solid Tumors or Lymphoma (Journal of Clinical Oncology, 2005)
- Phase 1 and pharmacologic study of MS-275, a histone deacetylase inhibitor, in adults with refractory and relapsed acute leukemias (Blood, 2006)
- Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies (Blood, 2009)
- MS-27-275, an Inhibitor of Histone Deacetylase, Has Marked in Vitro and in Vivo Antitumor Activity against Pediatric Solid Tumors (Cancer Research, 2002)
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Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - MS 275
- MS-27-275
- N-(2-aminophenyl)-4-(N-(pyridin-3-ylmethoxycarbonyl)aminomethyl)benzamide
- MS-275
- SNDX-275
- MS 27-275
-
SMILESC1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)CNC(=O)OCC3=CN=CC=C3
-
InChIKeyINVTYAOGFAGBOE-UHFFFAOYSA-N
- Pubchem - Entinostat
- Wikipedia - entinostat
Entinostat, also known as SNDX-275 and MS-275, is a benzamide histone deacetylase inhibitor undergoing clinical trials for treatment of various cancers. Entinostat inhibits class I HDAC1 and HDAC3 with IC50 of 0.51 M and 1.7 M, respectively. Syndax pharmaceuticals currently holds the rights to Entinostat and recently received $26.6 million in funds to advance treatments of resistant cancers using epigenetic tools.
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