Weight | 414.41 g/mol |
---|---|
Formula | C22H22O8 |
Hydrogen Acceptors | 8 |
Hydrogen Donors | 1 |
Aromatic Rings | 2 |
Rotatable Bonds | 4 |
Epipodophyllotoxin (4375-07-9)
Score:
#2181 in Biochemistry
,
#5626 in Chemistry
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- Role of topoisomerase II in mediating epipodophyllotoxin-induced DNA cleavage. (Cancer Research, 1984)
- Letter: Epipodophyllotoxin in mycosis fungoides. (The Lancet, 1975)
- Successful treatment of lymphohistiocytic reticulosis with phagocytosis with epipodophyllotoxin VP 16213 (Cancer, 1980)
- Characterization of acquired epipodophyllotoxin resistance in a Chinese hamster ovary cell line: loss of drug-stimulated DNA cleavage activity. (Cancer Research, 1986)
- Epipodophyllotoxin-related leukemia. Identification of a new subset of secondary leukemia (Cancer, 1991)
- Treatment of four patients with erythrophagocytic lymphohistiocytosis by a combination of epipodophyllotoxin, steroids, intrathecal methotrexate, and cranial irradiation. (Pediatrics, 1985)
-
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCOC1=CC(=CC(=C1OC)OC)C2C3C(COC3=O)C(C4=CC5=C(C=C24)OCO5)O
-
InChIKeyYJGVMLPVUAXIQN-UHFFFAOYSA-N
- Pubchem - Epipodophyllotoxin
- Wikipedia - Epipodophyllotoxin
Epipodophyllotoxins are substances naturally occurring in the root of American Mayapple plant (Podophyllum peltatum). Some epipodophyllotoxin derivatives are currently used in the treatment of cancer. These include etoposide and teniposide.
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