Weight | 345.407 g/mol |
---|---|
Formula | C16H23N7O2 |
Hydrogen Acceptors | 9 |
Hydrogen Donors | 0 |
Aromatic Rings | 2 |
Rotatable Bonds | 6 |
Eptapirone (179756-85-5)
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SMILESCN1C(=O)C=NN(C1=O)CCCCN2CCN(CC2)C3=NC=CC=N3
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InChIKeyNMYAHEULKSYAPP-UHFFFAOYSA-N
- Pubchem - Eptapirone
- Wikipedia - eptapirone
Eptapirone (F-11,440) is a very potent and highly selective 5-HT1A receptor full agonist of the azapirone family. Its affinity for the 5-HT1A receptor was reported to be 4.8 nM (Ki) (or 8.33 (pKi)), and its intrinsic activity approximately equal to that of serotonin (i.e., 100%). Eptapirone and related high-efficacy 5-HT1A full and super agonists such as befiradol and F-15,599 were developed under the hypothesis that the maximum exploitable therapeutic benefits of 5-HT1A receptor agonists might not be able to be seen without the drugs employed possessing sufficiently high intrinsic activity at the receptor.
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