Weight | 237.73 g/mol |
---|---|
Formula | C13H16ClNO |
Hydrogen Acceptors | 2 |
Hydrogen Donors | 1 |
Aromatic Rings | 1 |
Rotatable Bonds | 2 |
Esketamine (33643-46-8)
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- Intravenous Esketamine in Adult Treatment-Resistant Depression: A Double-Blind, Double-Randomization, Placebo-Controlled Study. (Biological Psychiatry, 2016)
- Loss of parvalbumin-immunoreactivity in mouse brain regions after repeated intermittent administration of esketamine, but not R-ketamine (Psychiatry Research-neuroimaging, 2016)
- Reduction of dopamine D2/3 receptor binding in the striatum after a single administration of esketamine, but not R-ketamine: a PET study in conscious monkeys. (European Archives of Psychiatry and Clinical Neuroscience, 2017)
- Metabolomic signatures of drug response phenotypes for ketamine and esketamine in subjects with refractory major depressive disorder: new mechanistic insights for rapid acting antidepressants (Translational Psychiatry, 2016)
- Esketamine for the treatment of treatment-refractory or treatment-resistant depression (2013)
- Pimobendan, etilefrine, moxifloxacin, and esketamine as reference compounds to validate the DSI Physiotel Digital System in cynomolgus monkeys (Journal of Pharmacological and Toxicological Methods, 2014)
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Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCNC1(CCCCC1=O)C2=CC=CC=C2Cl
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InChIKeyYQEZLKZALYSWHR-UHFFFAOYSA-N
- Pubchem - Esketamine
- Wikipedia - esketamine
Esketamine, sold under the brand names Ketanest and Ketanest S, also known as (S)-ketamine or S(+)-ketamine, is a general anesthetic and a dissociative hallucinogen. It is the S(+) enantiomer of the drug ketamine, which is an anesthetic and dissociative similarly. Esketamine acts primarily as a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist.
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