| Weight | 289.339 g/mol |
|---|---|
| Formula | C14H19N5O2 |
| Hydrogen Acceptors | 7 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 5 |
etazolate (51022-77-6)
SQ 20009 · SQ-20009 · SQ20009
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- Enhancement of the binding of 3H-diazepam to rat brain membranes in vitro by SQ 20009, a novel anxiolytic, -aminobutyric acid (GABA) and muscimol (Life Sciences, 1979)
- Etazolate, a neuroprotective drug linking GABAA receptor pharmacology to amyloid precursor protein processing (Journal of Neurochemistry, 2008)
- In vitro modulations by SQ 20009 and SQ 65396 of GABA receptor binding in rat CNS membranes (European Journal of Pharmacology, 1980)
- 1-ethyl-4-(isopropylidenehydrazino)-1H-pyrazolo-(3,4-b)-pyridine-5-carboxylic acid, ethyl ester, hydrochloride (SQ 20009)a potent new inhibitor of cyclic 3,5-nucleotide phosphodiesterases (Biochemical Pharmacology, 1972)
- Stimulation of benzodiazepine receptor binding by SQ 20009 is chloride-dependent and picrotoxin-sensitive (European Journal of Pharmacology, 1979)
- Interaction of SQ 20009 and GABA-like drugs as modulators of benzodiazepine receptor binding (European Journal of Pharmacology, 1980)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - SQ 20009
- SQ-20009
- SQ20009
- Etazolate Hydrochloride
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SMILESCCN1C2=NC=C(C(=C2C=N1)NN=C(C)C)C(=O)OCC
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- Pubchem - etazolate
- Wikipedia - etazolate
Etazolate (SQ-20,009, EHT-0202) is an anxiolytic drug which is a pyrazolopyridine derivative and has unique pharmacological properties. It acts as a positive allosteric modulator of the GABAA receptor at the barbiturate binding site, as an adenosine antagonist of the A1 and A2 subtypes, and as a phosphodiesterase inhibitor selective for the PDE4 isoform. It is currently in clinical trials for the treatment of Alzheimer's disease.
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