ethambutol (75343-56-5, 74-55-5)

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Suppliers

• Sigma-Aldrich - Search for ethambutol
• Fisher Scientific - Search for ethambutol
• TCI - Search for ethambutol

Most-cited Publications

• The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutol (Proceedings of the National Academy of Sciences of the United States of America, 1996)
• The emb operon, a gene cluster of Mycobacterium tuberculosis involved in resistance to ethambutol (Nature Medicine, 1997)
• A Comparison of Two Regimens for the Treatment of Mycobacterium avium Complex Bacteremia in AIDS: Rifabutin, Ethambutol, and Clarithromycin versus Rifampin, Ethambutol, Clofazimine, and Ciprofloxacin (The New England Journal of Medicine, 1996)
• Moxifloxacin versus ethambutol in the initial treatment of tuberculosis: a double-blind, randomised, controlled phase II trial (The Lancet, 2009)
• Inhibition of synthesis of arabinogalactan by ethambutol in Mycobacterium smegmatis. (Antimicrobial Agents and Chemotherapy, 1989)
• Moxifloxacin versus Ethambutol in the First 2 Months of Treatment for Pulmonary Tuberculosis (American Journal of Respiratory and Critical Care Medicine, 2006)

Areas of Application

Safety

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Trends

Alternate Names

• Myambutol
• Ethambutol Hydrochloride
• Etibi
• EMB Fatol
• EMB Hefa
• Miambutol
• EMB-Hefa
• Dexambutol
• EMB-Fatol
• Etambutol Llorente
• SMILES
  CCC(CO)NCCNC(CC)CO
• InChIKey
  AEUTYOVWOVBAKS-UHFFFAOYSA-N

External Links

• Pubchem - ethambutol
• Wikipedia - ethambutol
  Ethambutol (EMB, E) is a medication primarily used to treat tuberculosis. It is usually given in combination with other tuberculosis medications, such as isoniazid, rifampicin and pyrazinamide. It may also be used to treat Mycobacterium avium complex, and Mycobacterium kansasii.

Synthesis

2-(2-aminoethylamino)butan-1-ol  +  2-chloro-1-butanol (Alkylation of primary amines)

Reactant  +  2-Aminobutan-1-ol (Reductive amination)

Synthesis of ethambutol ›

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