| Weight | 300.789 g/mol |
|---|---|
| Formula | C17H17ClN2O |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 2 |
Etifoxine (21715-46-8)
Score:
#1050 in Neuroscience
,
#4559 in Biology
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- The anxiolytic etifoxine activates the peripheral benzodiazepine receptor and increases the neurosteroid levels in rat brain (Pharmacology, Biochemistry and Behavior, 2005)
- Etifoxine improves peripheral nerve regeneration and functional recovery (Proceedings of the National Academy of Sciences of the United States of America, 2008)
- Modulation of GABAergic synaptic transmission by the non-benzodiazepine anxiolytic etifoxine (Neuropharmacology, 2000)
- Efficacy of etifoxine compared to lorazepam monotherapy in the treatment of patients with adjustment disorders with anxiety: a double-blind controlled study in general practice. (Human Psychopharmacology-clinical and Experimental, 2006)
- The modulatory effects of the anxiolytic etifoxine on GABAA receptors are mediated by the subunit (Neuropharmacology, 2003)
- [Treatment of adjustment disorder with anxiety: efficacy and tolerance of etifoxine in a double-blind controlled study]. (Encephale-revue De Psychiatrie Clinique Biologique Et Therapeutique, 1998)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCCNC1=NC2=C(C=C(C=C2)Cl)C(O1)(C)C3=CC=CC=C3
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InChIKeyIBYCYJFUEJQSMK-UHFFFAOYSA-N
- Pubchem - Etifoxine
- Wikipedia - etifoxine
Etifoxine (INN, also known as etafenoxine; trade name Stresam) is an anxiolytic and anticonvulsant drug developed by Hoechst in the 1960s. It is sold in approximately 40 countries for anxiety disorders, without the sedation and ataxia associated with benzodiazepine drugs. It has similar anxiolytic effects to benzodiazepine drugs, but is structurally distinct and does not bind to the benzodiazepine receptor.
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Synthesis
Reactant
+
1-(2-amino-5-chlorophenyl)-1-phenylethanol
(Imine formation from aldehyde)
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