| Weight | 546.623 g/mol |
|---|---|
| Formula | C34H30N2O5 |
| Hydrogen Acceptors | 6 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 5 |
| Rotatable Bonds | 12 |
Farglitazar (196808-45-4)
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- Farglitazar lacks antifibrotic activity in patients with chronic hepatitis C infection. (Gastroenterology, 2010)
- Genetic variants in the epithelial sodium channel associate with oedema in type 2 diabetic patients receiving the peroxisome proliferator-activated receptor gamma agonist farglitazar (Pharmacogenetics and Genomics, 2007)
- Double blind, randomized, placebo-controlled, multi-center,phase II dose ranging study to assess the antifibrotic activityof farglitazar in chronic hepatitis C infection. (Hepatology, 2008)
- The Degradation Chemistry of Farglitazar and Elucidation of the Oxidative Degradation Mechanisms (Journal of Pharmaceutical Sciences, 2017)
- Farglitazar lacks antibrotic activity in patients with chronic hepatitis C infection (Gastroenterology, 2010)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC1=C(N=C(O1)C2=CC=CC=C2)CCOC3=CC=C(C=C3)CC(C(=O)O)NC4=CC=CC=C4C(=O)C5=CC=CC=C5
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InChIKeyZZCHHVUQYRMYLW-UHFFFAOYSA-N
- Pubchem - Farglitazar
- Wikipedia - farglitazar
Farglitazar is a peroxisome proliferator-activated receptor agonist which is being developed by GlaxoSmithKline for the treatment of hepatic fibrosis. It is currently in phase II clinical trials.
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Synthesis
2-Aminobenzophenone
+
Reactant
(Alkylation of primary amines)
5-Methyl-2-phenyloxazole
+
Reactant
(Friedel-Crafts alkylation)
N-(2-benzoylphenyl)-L-tyrosine
+
Reactant
(Williamson ether)
Reactant
+
CHLOROBENZENE
(Decarboxylative coupling)
Reactant
+
CHLOROBENZENE
(Grignard carbonyl)
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