Weight | 315.46 g/mol |
---|---|
Formula | C23H25N |
Hydrogen Acceptors | 1 |
Hydrogen Donors | 1 |
Aromatic Rings | 3 |
Rotatable Bonds | 7 |
fendiline (13042-18-7)
Sensit · Fendilin · Senzit
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- Fendiline inhibits K-Ras plasma membrane localization and blocks K-Ras signal transmission. (Molecular and Cellular Biology, 2013)
- Fendiline: a review of its basic pharmacological and clinical properties. (1987)
- Open State Block by Fendiline of L-Type Ca++ Channels in Ventricular Myocytes from Rat Heart (Journal of Pharmacology and Experimental Therapeutics, 1998)
- Fendiline increases [Ca2+]i in Madin Darby canine kidney (MDCK) cells by releasing internal Ca2+ followed by capacitative Ca2+ entry. (Life Sciences, 2000)
- Fendiline and calmidazolium enhance the release of endothelium-derived relaxant factor and of prostacyclin from cultured endothelial cells (Naunyn-schmiedebergs Archives of Pharmacology, 1988)
- Fendiline-evoked [Ca2+]i rises and non-Ca2+-triggered cell death in human oral cancer cells. (Human & Experimental Toxicology, 2009)
-
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Sensit
- Fendilin
- Senzit
- Fendiline Hydrochloride
-
SMILESCC(C1=CC=CC=C1)NCCC(C2=CC=CC=C2)C3=CC=CC=C3
-
InChIKeyNMKSAYKQLCHXDK-UHFFFAOYSA-N
- Pubchem - fendiline
- Wikipedia - fendiline
Fendiline is a calcium channel blocker. It is nonselective.
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Synthesis
Reactant
+
1-Phenylethanamine
(Reductive amination)
benzene
+
Reactant
(Friedel-Crafts alkylation)
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