| Weight | 266.688 g/mol |
|---|---|
| Formula | C11H11ClN4O2 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 1 |
Fenobam (57653-26-6)
Score:
#1024 in Neuroscience
,
#4465 in Biology
,
#5655 in Chemistry
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- Sigma-Aldrich - Fenobam90.20 - 337.00 USD
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- A pilot open-label single-dose trial of fenobam in adults with fragile X syndrome (Journal of Medical Genetics, 2009)
- Fenobam: A Clinically Validated Nonbenzodiazepine Anxiolytic Is a Potent, Selective, and Noncompetitive mGlu5 Receptor Antagonist with Inverse Agonist Activity (Journal of Pharmacology and Experimental Therapeutics, 2005)
- Treatment of Anxiety Using Fenobam (a Nonbenzodiazepine) in a Double-Blind Standard (Diazepam) Placebo-Controlled Study (Journal of Clinical Psychopharmacology, 1982)
- The metabotropic glutamate receptor subtype 5 antagonist fenobam is analgesic and has improved in vivo selectivity compared with the prototypical antagonist 2-methyl-6-(phenylethynyl)-pyridine. (Journal of Pharmacology and Experimental Therapeutics, 2009)
- The anxiolytic and analgesic properties of fenobam, a potent mGlu5 receptor antagonist, in relation to the impairment of learning (Neuropharmacology, 2009)
- Attenuation of reinstatement of methamphetamine-, sucrose-, and food-seeking behavior in rats by fenobam, a metabotropic glutamate receptor 5 negative allosteric modulator (Psychopharmacology, 2013)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCN1CC(=O)N=C1NC(=O)NC2=CC(=CC=C2)Cl
-
InChIKeyDWPQODZAOSWNHB-UHFFFAOYSA-N
- Pubchem - Fenobam
- Wikipedia - fenobam anhydrous
Fenobam is an imidazole derivative developed by McNeil Laboratories in the late 1970s as a novel anxiolytic drug with an at-the-time-unidentified molecular target in the brain. Subsequently, it was determined that fenobam acts as a potent and selective negative allosteric modulator of the metabotropic glutamate receptor subtype mGluR5, and it has been used as a lead compound for the development of a range of newer mGluR5 antagonists. Fenobam has anxiolytic effects comparable to those of benzodiazepine drugs, but was never commercially marketed for the treatment of anxiety due to dose-limiting side effects such as amnesia and psychotomimetic symptoms.
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