| Weight | 414.346 g/mol |
|---|---|
| Formula | C17H20F6N2O3 |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 7 |
flecainide (54143-55-4)
Tambocor · Flecainide Acetate · Flecainide, 5-HO-N-(6-oxo)-Derivative, (+-)-Isomer
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#10 in Physiology
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#3161 in Chemistry
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- Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial. (The New England Journal of Medicine, 1991)
- Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans. (Nature Medicine, 2009)
- Prevention of symptomatic recurrences of paroxysmal atrial fibrillation in patients initially tolerating antiarrhythmic therapy. A multicenter, double-blind, crossover study of flecainide and placebo with transtelephonic monitoring (Circulation, 1989)
- Flecainide therapy reduces exercise-induced ventricular arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia (Journal of the American College of Cardiology, 2011)
- Flecainide: Its proarrhythmic effect and expected changes on the surface electrocardiogram (American Journal of Cardiology, 1984)
- The Elusive Link Between LQT3 and Brugada Syndrome The Role of Flecainide Challenge (Circulation, 2000)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Tambocor
- Flecainide Acetate
- Flecainide, 5-HO-N-(6-oxo)-Derivative, (+-)-Isomer
- Flecatab
- Flecainide Monoacetate, (R)-Isomer
- Flecainide, (S)-Isomer
- Alpharma Brand of Flecainide Acetate
- Alphapharm Brand of Flecainide Acetate
- Flecainide, (R)-Isomer
- Riker Brand of Flecainide Acetate
- Flecainide Monoacetate
- Merck dura Brand of Flecainide Acetate
- Flecainid Isis
- 3M Brand of Flecainide Acetate
- Flecainide, 5-HO-N-(6-oxo)-Derivative
- Flcane
- Flecadura
- Flecainide Monoacetate, (+-)-Isomer
- Apocard
- Flecainide Monoacetate, (S)-Isomer
- United Drug Brand of Flecainide Acetate
- R818
- Flecainid-Isis
-
SMILESC1CCNC(C1)CNC(=O)C2=C(C=CC(=C2)OCC(F)(F)F)OCC(F)(F)F
-
InChIKeyDJBNUMBKLMJRSA-UHFFFAOYSA-N
- Pubchem - flecainide
- Wikipedia - flecainide
Flecainide acetate ( flek-AY-nyde) is a class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias (abnormal fast rhythms of the heart). It is used to treat a variety of cardiac arrhythmias including paroxysmal atrial fibrillation (episodic irregular heartbeat originating in the upper chamber of the heart), paroxysmal supraventricular tachycardia (episodic rapid but regular heartbeat originating in the atrium), and ventricular tachycardia (rapid rhythms of the lower chambers of the heart). Flecainide works by regulating the flow of sodium in the heart, causing prolongation of the cardiac action potential.
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Synthesis
Reactant
+
2-(chloromethyl)piperidine
(Alkylation of primary amines)
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flecainide
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