Weight | 453.879 g/mol |
---|---|
Formula | C19H17ClFN3O5S |
Hydrogen Acceptors | 6 |
Hydrogen Donors | 2 |
Aromatic Rings | 2 |
Rotatable Bonds | 4 |
Flucloxacillin (5250-39-5, 1847-24-1)
Floxacillin · Fluorochloroxacillin
Score:
#378 in Microbiology
,
#2961 in Biology
,
#3703 in Chemistry
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- HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin (Nature Genetics, 2009)
- Mucoid Pseudomonas aeruginosa and cystic fibrosis: resistance of the mucoid form to carbenicillin, flucloxacillin and tobramycin and the isolation of mucoid variants in vitro (Journal of Antimicrobial Chemotherapy, 1978)
- Flucloxacillin, a New Isoxazolyl Penicillin, Compared with Oxacillin, Cloxacillin, and Dicloxacillin (BMJ, 1970)
- Early termination of a prospective, randomized trial comparing teicoplanin and flucloxacillin for treating severe staphylococcal infections. (The Journal of Infectious Diseases, 1987)
- Liver damage from flucloxacillin, cloxacillin and dicloxacillin (Journal of Hepatology, 1992)
- Prognosis in cystic fibrosis treated with continuous flucloxacillin from the neonatal period. (Archives of Disease in Childhood, 1994)
-
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Floxacillin
- Fluorochloroxacillin
-
SMILESCC1=C(C(=NO1)C2=C(C=CC=C2Cl)F)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)O
-
InChIKeyUIOFUWFRIANQPC-UHFFFAOYSA-N
- Pubchem - Flucloxacillin
- Wikipedia - flucloxacillin
Flucloxacillin (INN) or floxacillin (USAN) is a narrow-spectrum beta-lactam antibiotic of the penicillin class. It is used to treat infections caused by susceptible Gram-positive bacteria. Unlike other penicillins, flucloxacillin has activity against beta-lactamase-producing organisms such as Staphylococcus aureus as it is beta-lactamase stable.
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Synthesis
3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carbonyl chloride
+
6-Aminopenicillanic acid
(Schotten-Baumann amide from acid)
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