| Weight | 303.293 g/mol |
|---|---|
| Formula | C15H14FN3O3 |
| Hydrogen Acceptors | 5 |
| Hydrogen Donors | 0 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 2 |
flumazenil (78755-81-4)
Ro 15-1788 · Romazicon · Anexate
Score:
#95 in Neurology
,
#483 in Neuroscience
,
#2223 in Biology
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- Benzodiazepine antagonist Ro 15-1788: neurological and behavioral effects. (Psychopharmacology, 1982)
- Compartmental Analysis of [11C]Flumazenil Kinetics for the Estimation of Ligand Transport Rate and Receptor Distribution Using Positron Emission Tomography (Journal of Cerebral Blood Flow and Metabolism, 1991)
- A three-state model of the benzodiazepine receptor explains the interactions between the benzodiazepine antagonist Ro 15-1788, benzodiazepine tranquilizers, -carbolines, and phenobarbitone (Naunyn-schmiedebergs Archives of Pharmacology, 1982)
- Intrinsic actions of the benzodiazepine receptor antagonist Ro 15-1788 (Psychopharmacology, 1986)
- Flumazenil provocation of panic attacks. Evidence for altered benzodiazepine receptor sensitivity in panic disorder. (Archives of General Psychiatry, 1990)
- Benzodiazepine antagonist Ro 15-1788: binding characteristics and interaction with drug-induced changes in dopamine turnover and cerebellar cGMP levels. (Journal of Neurochemistry, 1982)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Ro 15-1788
- Romazicon
- Anexate
- Ro 151788
- Ro 15 1788
- Flumazepil
- Hoffman La Roche Brand of Flumazenil
- Lanexat
- Roche Brand of Flumazenil
- Hoffman-La Roche Brand of Flumazenil
-
SMILESCCOC(=O)C1=C2CN(C(=O)C3=C(N2C=N1)C=CC(=C3)F)C
-
InChIKeyOFBIFZUFASYYRE-UHFFFAOYSA-N
- Pubchem - flumazenil
- Wikipedia - flumazenil
Flumazenil (also known as flumazepil, code name Ro 15-1788) is a selective benzodiazepine receptor antagonist available by injection and intranasal. It has antagonistic and antidote properties to therapeutically used benzodiazepines, through competitive inhibition. It was first introduced in 1987 by Hoffmann-La Roche under the trade name Anexate, but only approved by the FDA on December 20, 1991.
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