Flupirtine (56995-20-1)

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Suppliers

• Sigma-Aldrich - Flupirtine
  215.50 USD
• Fisher Scientific - Search for Flupirtine
• TCI - Search for Flupirtine

Most-cited Publications

• Efficacy of flupirtine on cognitive function in patients with CJD A double-blind study (Neurology, 2004)
• Flupirtine shows functional NMDA receptor antagonism by enhancing Mg2+ block via activation of voltage independent potassium channels (Journal of Neural Transmission, 1999)
• Flupirtine. A review of its pharmacological properties, and therapeutic efficacy in pain states. (Drugs, 1993)
• Effect of flupirtine on Bcl-2 and glutathione level in neuronal cells treated in vitro with the prion protein fragment (PrP106-126) (Experimental Neurology, 1997)
• Protection of rabbit retina from ischemic injury by flupirtine. (Investigative Ophthalmology & Visual Science, 1996)
• Protection of Flupirtine on -Amyloid-Induced Apoptosis in Neuronal Cells In Vitro: Prevention of Amyloid-Induced Glutathione Depletion (Journal of Neurochemistry, 2002)

Areas of Application

Safety

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Trends

Alternate Names

• D 9998
• Katadolon
• D-9998
• flupirtine maleate (1:1)
• flupirtin maleate
• ethyl 2-amino-6-((p-fluorobenzyl)amino)-3-pyridinecarbamate
• SMILES
  CCOC(=O)NC1=C(N=C(C=C1)NCC2=CC=C(C=C2)F)N
• InChIKey
  JUUFBMODXQKSTD-UHFFFAOYSA-N

External Links

• Pubchem - Flupirtine
• Wikipedia - flupirtine
  Flupirtine is an aminopyridine that functions as a centrally acting non-opioid analgesic that was originally used as an analgesic for acute and chronic pain but in 2013 due to issues with liver toxicity, the European Medicines Agency restricted its use to acute pain, for no more than two weeks, and only for people who cannot use other painkillers. Flupirtine is a selective neuronal potassium channel opener (SNEPCO) that also has NMDA receptor antagonist and GABAA receptor modulatory properties. It first became available in Europe in 1984 under the brand name Katadolon and after it went off patent many generic brands were introduced.

Synthesis

Reactant  +  4-Fluorobenzyl chloride (Alkylation of primary amines)

Synthesis of Flupirtine ›

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