| Weight | 315.694 g/mol |
|---|---|
| Formula | C9H19ClN3O5P |
| Hydrogen Acceptors | 6 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 0 |
| Rotatable Bonds | 9 |
Fotemustine (92118-27-9)
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- Fotemustine compared with dacarbazine in patients with disseminated malignant melanoma: a phase III study. (Journal of Clinical Oncology, 2004)
- Final Report of the French Multicenter Phase II Study of the Nitrosourea Fotemustine in 153 Evaluable Patients With Disseminated Malignant Melanoma Including Patients With Cerebral Metastases (Cancer, 1990)
- Ipilimumab and fotemustine in patients with advanced melanoma (NIBIT-M1): an open-label, single-arm phase 2 trial (Lancet Oncology, 2012)
- Treatment of disseminated ocular melanoma with sequential fotemustine, interferon , and interleukin 2 (British Journal of Cancer, 2002)
- A prospective randomized multicentre phase III trial of fotemustine plus whole brain irradiation versus fotemustine alone in cerebral metastases of malignant melanoma. (Melanoma Research, 2003)
- Intra-arterial hepatic fotemustine for the treatment of liver metastases from uveal melanoma: experience in 101 patients (Annals of Oncology, 2006)
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SMILESCCOP(=O)(C(C)NC(=O)N(CCCl)N=O)OCC
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- Pubchem - Fotemustine
- Wikipedia - fotemustine
Fotemustine is a nitrosourea alkylating agent approved for use in the treatment of metastasising melanoma. A study has shown that fotemustine produces improved response rates and but does not increase survival (over dacarbazine in the treatment of disseminated cutaneous melanoma. Median survival was 7.3 months with fotemustine versus 5.6 months with DTIC (P=.067).
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Synthesis
1-Isocyanatoethylphosphonic acid diethyl ester
+
Reactant
(Thiourea)
Reactant
+
Phosphonic acid, (1-aminoethyl)-, diethyl ester
(Schotten-Baumann amide from acid)
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Fotemustine
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