| Weight | 140.142 g/mol |
|---|---|
| Formula | C6H8N2O2 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 0 |
gaboxadol (64603-91-4)
THIP · LU-2-030 · 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol
Score:
#997 in Neuroscience
,
#4371 in Biology
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- GABAA receptor 4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol (Proceedings of the National Academy of Sciences of the United States of America, 2006)
- A comparison of the antinociceptive responses to the GABA-receptor agonists THIP and baclofen (Neuropharmacology, 1985)
- THIP, a Hypnotic and Antinociceptive Drug, Enhances an Extrasynaptic GABAA Receptor-mediated Conductance in Mouse Neocortex (Cerebral Cortex, 2006)
- Analgesic properties of the GABA-minetic thip (European Journal of Pharmacology, 1981)
- The GABAA agonist THIP produces slow wave sleep and reduces spindling activity in NREM sleep in humans. (Psychopharmacology, 1997)
- Gaboxadol a new awakening in sleep (Current Opinion in Pharmacology, 2006)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - THIP
- LU-2-030
- 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol
- LU 2030
-
SMILESC1CNCC2=C1C(=O)NO2
-
InChIKeyZXRVKCBLGJOCEE-UHFFFAOYSA-N
- Pubchem - gaboxadol
- Wikipedia - gaboxadol
Gaboxadol, also known as 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol (THIP), is a conformationally constrained derivative of the alkaloid muscimol that was first synthesized in 1977 by the Danish chemist Povl Krogsgaard-Larsen. In the early 1980s gaboxadol was the subject of a series of pilot studies that tested its efficacy as an analgesic and anxiolytic, as well as a treatment for tardive dyskinesia, Huntington's disease, Alzheimer's disease, and spasticity. It was not until 1996 that researchers attempted to harness gaboxadol's frequently reported sedative "adverse effect" for the treatment of insomnia, resulting in a series of clinical trials sponsored by Lundbeck and Merck.
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